Nuclearly-encoded CBP1 interacts with the 5′ end of mitochondrial cytochrome b pre-mRNA

Carol L. Dieckmann, Telsa M. Mittelmeier

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

CBP1 is a nuclearly-encoded protein that is imported into mitochondria and confers stability on the mRNA for cytochrome b. Previous work has shown that CBP1 interacts with the cytochrome b transcript upstream of the coding sequence; a region encompassing some 1,100 nucleotides. The work presented here narrows the site of action of CBP1 to the distal third of this upstream sequence through analysis of mRNA produced from a novel recombinant gene containing segments of the gene for cytochrome b, cob, and the ATP synthase subunit 9 gene, olil. In a wild-type CBP1 strain, the cob-olil-cob gene produces stable, mature mRNA that is translated and contributes a portion of the cytochrome b necessary for optimal growth on non-fermentable medium.

Original languageEnglish (US)
Pages (from-to)391-397
Number of pages7
JournalCurrent Genetics
Volume12
Issue number6
DOIs
StatePublished - Oct 1987

Keywords

  • Mitochondrial gene fusions
  • Organelle biogenesis
  • RNA processing
  • Yeast mitochondria

ASJC Scopus subject areas

  • Genetics

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