Numerical model of full-cardiac cycle hemodynamics in a total artificial heart and the effect of its size on platelet activation

Gil Marom, Wei Che Chiu, Jessica R. Crosby, Katrina J. DeCook, Saurabh Prabhakar, Marc Horner, Marvin J. Slepian, Danny Bluestein

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

The SynCardia total artificial heart (TAH) is the only Food and Drug Administration (FDA) approved device for replacing hearts in patients with congestive heart failure. It pumps blood via pneumatically driven diaphragms and controls the flow with mechanical valves. While it has been successfully implanted in more than 1300 patients, its size precludes implantation in smaller patients. This study’s aim was to evaluate the viability of scaled-down TAHs by quantifying thrombogenic potentials from flow patterns. Simulations of systole were first conducted with stationary valves, followed by an advanced full-cardiac cycle model with moving valves. All the models included deforming diaphragms and platelet suspension in the blood flow. Flow stress accumulations were computed for the platelet trajectories and thrombogenic potentials were assessed. The simulations successfully captured complex flow patterns during various phases of the cardiac cycle. Increased stress accumulations, but within the safety margin of acceptable thrombogenicity, were found in smaller TAHs, indicating that they are clinically viable.

Original languageEnglish (US)
Pages (from-to)788-796
Number of pages9
JournalJournal of cardiovascular translational research
Volume7
Issue number9
DOIs
StatePublished - Nov 25 2014

Keywords

  • Computational fluid dynamics
  • Fluid–structure interaction
  • Mechanical circulatory support devices
  • Thrombogenic potential
  • Total artificial heart

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)

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