Abstract
The aim of this study was to examine if five single nucleotide polymorphisms involved in one-carbon metabolism are associated with the efficiency of iAs metabolism and if these potential associations are respectively modified by dietary intake of folate-related nutrients. Most of the nutrients and polymorphisms altered the iAs metabolism. Additionally, vitamin B12 and methionine modified the association between FolH1 T223C and MTR A2756G over the iAs metabolism, respectively. Genetic and dietary differences in one-carbon metabolism may jointly account for differences in iAs metabolism.
| Original language | English (US) |
|---|---|
| Title of host publication | One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment |
| Publisher | CRC Press/Balkema |
| Pages | 495-497 |
| Number of pages | 3 |
| ISBN (Print) | 9781138001411 |
| State | Published - 2014 |
| Event | 5th International Congress on Arsenic in the Environment, As 2014 - Buenos Aires, Argentina Duration: May 11 2014 → May 16 2014 |
Other
| Other | 5th International Congress on Arsenic in the Environment, As 2014 |
|---|---|
| Country | Argentina |
| City | Buenos Aires |
| Period | 5/11/14 → 5/16/14 |
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ASJC Scopus subject areas
- Chemical Health and Safety
Cite this
Nutrients and genetic polymorphisms modify arsenic metabolism efficiency. / Hernández-Alcaraz, C.; Hernández-Ramírez, R. U.; García-Martínez, A.; Burguete-García, A. I.; López-Carrillo, L.; Cebrián, M. E.; Gandolfi, A Jay.
One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment. CRC Press/Balkema, 2014. p. 495-497.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Nutrients and genetic polymorphisms modify arsenic metabolism efficiency
AU - Hernández-Alcaraz, C.
AU - Hernández-Ramírez, R. U.
AU - García-Martínez, A.
AU - Burguete-García, A. I.
AU - López-Carrillo, L.
AU - Cebrián, M. E.
AU - Gandolfi, A Jay
PY - 2014
Y1 - 2014
N2 - The aim of this study was to examine if five single nucleotide polymorphisms involved in one-carbon metabolism are associated with the efficiency of iAs metabolism and if these potential associations are respectively modified by dietary intake of folate-related nutrients. Most of the nutrients and polymorphisms altered the iAs metabolism. Additionally, vitamin B12 and methionine modified the association between FolH1 T223C and MTR A2756G over the iAs metabolism, respectively. Genetic and dietary differences in one-carbon metabolism may jointly account for differences in iAs metabolism.
AB - The aim of this study was to examine if five single nucleotide polymorphisms involved in one-carbon metabolism are associated with the efficiency of iAs metabolism and if these potential associations are respectively modified by dietary intake of folate-related nutrients. Most of the nutrients and polymorphisms altered the iAs metabolism. Additionally, vitamin B12 and methionine modified the association between FolH1 T223C and MTR A2756G over the iAs metabolism, respectively. Genetic and dietary differences in one-carbon metabolism may jointly account for differences in iAs metabolism.
UR - http://www.scopus.com/inward/record.url?scp=84907369500&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907369500&partnerID=8YFLogxK
M3 - Conference contribution
AN - SCOPUS:84907369500
SN - 9781138001411
SP - 495
EP - 497
BT - One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
PB - CRC Press/Balkema
ER -