TY - GEN
T1 - Nutrients and genetic polymorphisms modify arsenic metabolism efficiency
AU - Hernández-Alcaraz, C.
AU - Hernández-Ramírez, R. U.
AU - García-Martínez, A.
AU - Burguete-García, A. I.
AU - López-Carrillo, L.
AU - Cebrián, M. E.
AU - Gandolfi, A. J.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2014
Y1 - 2014
N2 - The aim of this study was to examine if five single nucleotide polymorphisms involved in one-carbon metabolism are associated with the efficiency of iAs metabolism and if these potential associations are respectively modified by dietary intake of folate-related nutrients. Most of the nutrients and polymorphisms altered the iAs metabolism. Additionally, vitamin B12 and methionine modified the association between FolH1 T223C and MTR A2756G over the iAs metabolism, respectively. Genetic and dietary differences in one-carbon metabolism may jointly account for differences in iAs metabolism.
AB - The aim of this study was to examine if five single nucleotide polymorphisms involved in one-carbon metabolism are associated with the efficiency of iAs metabolism and if these potential associations are respectively modified by dietary intake of folate-related nutrients. Most of the nutrients and polymorphisms altered the iAs metabolism. Additionally, vitamin B12 and methionine modified the association between FolH1 T223C and MTR A2756G over the iAs metabolism, respectively. Genetic and dietary differences in one-carbon metabolism may jointly account for differences in iAs metabolism.
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U2 - 10.1201/b16767-185
DO - 10.1201/b16767-185
M3 - Conference contribution
AN - SCOPUS:84907369500
SN - 9781138001411
T3 - One Century of the Discovery of Arsenicosis in Latin America (1914-2014): As 2014 - Proceedings of the 5th International Congress on Arsenic in the Environment
SP - 495
EP - 497
BT - One Century of the Discovery of Arsenicosis in Latin America (1914-2014)
PB - CRC Press/Balkema
T2 - 5th International Congress on Arsenic in the Environment, As 2014
Y2 - 11 May 2014 through 16 May 2014
ER -