Nutrients in one-carbon metabolism and urinary arsenic methylation in the National Health and Nutrition Examination Survey (NHANES) 2003–2004

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Abstract

Exposure to inorganic arsenic (inAs), a potent toxicant, occurs primarily through ingestion of food and water. The efficiency with which it is methylated to mono and dimethyl arsenicals (MMA and DMA) affects toxicity. Folate, vitamins B12 and B6 are required for 1C metabolism, and studies have found that higher levels of these nutrients increase methylation capacity and are associated with protection against adverse health effects from inAs, especially in undernourished populations. Our aim was to determine whether 1C-related nutrients are associated with greater inAs methylation capacity in a general population sample with overall adequate nutrition and low levels of As exposure. Univariate and multivariable regression models were used to evaluate the relationship of dietary and blood nutrients to urinary As methylation in the National Health and Nutrition Examination Survey (NHANES) 2003–2004. Outcome variables were the percent of the sum of inAs and methylated As species (inAs + MMA + DMA) excreted as inAs, MMA, and DMA, and the ratio of MMA:DMA. In univariate models, dietary folate, vitamin B6 and protein intake were associated with lower urinary inAs% and greater DMA% in adults (≥ 18 years), with similar trends in children (6–18). In adjusted models, vitamin B6 intake (p = 0.011) and RBC folate (p = 0.036) were associated with lower inAs%, while dietary vitamin B12 was associated with higher inAs% (p = 0.002) and lower DMA% (p = 0.030). Total plasma homocysteine was associated with higher MMA% (p = 0.004) and lower DMA% (p = 0.003), but not with inAs%; other blood nutrients showed no association with urinary As. Although effect size is small, these findings suggest that 1C nutrients can influence inAs methylation and potentially play an indirect role in reducing toxicity in a general population sample.

Original languageEnglish (US)
Pages (from-to)381-390
Number of pages10
JournalScience of the Total Environment
Volume607-608
DOIs
StatePublished - Dec 31 2017

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health and nutrition
Methylation
methylation
Arsenic
Nutrition
Metabolism
Nutrients
arsenic
Carbon
metabolism
Health
Dynamic mechanical analysis
nutrient
carbon
Vitamins
vitamin
Vitamin B 6
Folic Acid
Vitamin B 12
Toxicity

Keywords

  • Arsenic
  • Dietary
  • Methylation
  • NHANES
  • One-carbon metabolism

ASJC Scopus subject areas

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution

Cite this

@article{e130dfdc43144cec904ddffedf2a20d8,
title = "Nutrients in one-carbon metabolism and urinary arsenic methylation in the National Health and Nutrition Examination Survey (NHANES) 2003–2004",
abstract = "Exposure to inorganic arsenic (inAs), a potent toxicant, occurs primarily through ingestion of food and water. The efficiency with which it is methylated to mono and dimethyl arsenicals (MMA and DMA) affects toxicity. Folate, vitamins B12 and B6 are required for 1C metabolism, and studies have found that higher levels of these nutrients increase methylation capacity and are associated with protection against adverse health effects from inAs, especially in undernourished populations. Our aim was to determine whether 1C-related nutrients are associated with greater inAs methylation capacity in a general population sample with overall adequate nutrition and low levels of As exposure. Univariate and multivariable regression models were used to evaluate the relationship of dietary and blood nutrients to urinary As methylation in the National Health and Nutrition Examination Survey (NHANES) 2003–2004. Outcome variables were the percent of the sum of inAs and methylated As species (inAs + MMA + DMA) excreted as inAs, MMA, and DMA, and the ratio of MMA:DMA. In univariate models, dietary folate, vitamin B6 and protein intake were associated with lower urinary inAs{\%} and greater DMA{\%} in adults (≥ 18 years), with similar trends in children (6–18). In adjusted models, vitamin B6 intake (p = 0.011) and RBC folate (p = 0.036) were associated with lower inAs{\%}, while dietary vitamin B12 was associated with higher inAs{\%} (p = 0.002) and lower DMA{\%} (p = 0.030). Total plasma homocysteine was associated with higher MMA{\%} (p = 0.004) and lower DMA{\%} (p = 0.003), but not with inAs{\%}; other blood nutrients showed no association with urinary As. Although effect size is small, these findings suggest that 1C nutrients can influence inAs methylation and potentially play an indirect role in reducing toxicity in a general population sample.",
keywords = "Arsenic, Dietary, Methylation, NHANES, One-carbon metabolism",
author = "Margaret Kurzius-Spencer and {da Silva}, Vanessa and Thomson, {Cynthia A.} and Vern Hartz and Hsu, {Chiu Hsieh} and Burgess, {Jefferey L.} and O'Rourke, {Mary Kay} and Harris, {Robin B.}",
year = "2017",
month = "12",
day = "31",
doi = "10.1016/j.scitotenv.2017.07.019",
language = "English (US)",
volume = "607-608",
pages = "381--390",
journal = "Science of the Total Environment",
issn = "0048-9697",
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TY - JOUR

T1 - Nutrients in one-carbon metabolism and urinary arsenic methylation in the National Health and Nutrition Examination Survey (NHANES) 2003–2004

AU - Kurzius-Spencer, Margaret

AU - da Silva, Vanessa

AU - Thomson, Cynthia A.

AU - Hartz, Vern

AU - Hsu, Chiu Hsieh

AU - Burgess, Jefferey L.

AU - O'Rourke, Mary Kay

AU - Harris, Robin B.

PY - 2017/12/31

Y1 - 2017/12/31

N2 - Exposure to inorganic arsenic (inAs), a potent toxicant, occurs primarily through ingestion of food and water. The efficiency with which it is methylated to mono and dimethyl arsenicals (MMA and DMA) affects toxicity. Folate, vitamins B12 and B6 are required for 1C metabolism, and studies have found that higher levels of these nutrients increase methylation capacity and are associated with protection against adverse health effects from inAs, especially in undernourished populations. Our aim was to determine whether 1C-related nutrients are associated with greater inAs methylation capacity in a general population sample with overall adequate nutrition and low levels of As exposure. Univariate and multivariable regression models were used to evaluate the relationship of dietary and blood nutrients to urinary As methylation in the National Health and Nutrition Examination Survey (NHANES) 2003–2004. Outcome variables were the percent of the sum of inAs and methylated As species (inAs + MMA + DMA) excreted as inAs, MMA, and DMA, and the ratio of MMA:DMA. In univariate models, dietary folate, vitamin B6 and protein intake were associated with lower urinary inAs% and greater DMA% in adults (≥ 18 years), with similar trends in children (6–18). In adjusted models, vitamin B6 intake (p = 0.011) and RBC folate (p = 0.036) were associated with lower inAs%, while dietary vitamin B12 was associated with higher inAs% (p = 0.002) and lower DMA% (p = 0.030). Total plasma homocysteine was associated with higher MMA% (p = 0.004) and lower DMA% (p = 0.003), but not with inAs%; other blood nutrients showed no association with urinary As. Although effect size is small, these findings suggest that 1C nutrients can influence inAs methylation and potentially play an indirect role in reducing toxicity in a general population sample.

AB - Exposure to inorganic arsenic (inAs), a potent toxicant, occurs primarily through ingestion of food and water. The efficiency with which it is methylated to mono and dimethyl arsenicals (MMA and DMA) affects toxicity. Folate, vitamins B12 and B6 are required for 1C metabolism, and studies have found that higher levels of these nutrients increase methylation capacity and are associated with protection against adverse health effects from inAs, especially in undernourished populations. Our aim was to determine whether 1C-related nutrients are associated with greater inAs methylation capacity in a general population sample with overall adequate nutrition and low levels of As exposure. Univariate and multivariable regression models were used to evaluate the relationship of dietary and blood nutrients to urinary As methylation in the National Health and Nutrition Examination Survey (NHANES) 2003–2004. Outcome variables were the percent of the sum of inAs and methylated As species (inAs + MMA + DMA) excreted as inAs, MMA, and DMA, and the ratio of MMA:DMA. In univariate models, dietary folate, vitamin B6 and protein intake were associated with lower urinary inAs% and greater DMA% in adults (≥ 18 years), with similar trends in children (6–18). In adjusted models, vitamin B6 intake (p = 0.011) and RBC folate (p = 0.036) were associated with lower inAs%, while dietary vitamin B12 was associated with higher inAs% (p = 0.002) and lower DMA% (p = 0.030). Total plasma homocysteine was associated with higher MMA% (p = 0.004) and lower DMA% (p = 0.003), but not with inAs%; other blood nutrients showed no association with urinary As. Although effect size is small, these findings suggest that 1C nutrients can influence inAs methylation and potentially play an indirect role in reducing toxicity in a general population sample.

KW - Arsenic

KW - Dietary

KW - Methylation

KW - NHANES

KW - One-carbon metabolism

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