Obesity cardiomyopathy and systolic function: Obesity is not independently associated with dilated cardiomyopathy

Muhammad Fahad Khan, Mohammad R Movahed

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Obesity is a growing worldwide problem and the prevalence of heart failure is also on the rise. Obesity itself is an independent risk factor for the development of heart failure and the case of obesity-related heart failure is thought to be multifactorial. Obesity leads to increased central and total blood volumes along with decreased systemic arterial resistance resulting in high cardiac output state related adaptations in the cardiac structure. Persistence of these hemodynamic changes ultimately results in diastolic dysfunction, however, whether these changes progress to significant systolic dysfunction or not is doubtful. Some MUGA (Multi Gated Acquisition) scan-based studies had shown mild degree of left ventricular systolic dysfunction in the obese, however, these findings could not be confirmed with recent echocardiogram-based studies. Using extensive literature review, we found no evidence of obesity-related cardiomyopathy leading to significant systolic dysfunction fulfilling criterion for the diagnosis of dilated cardiomyopathy (LVEF <35 %). Therefore, any obese patient presenting with severe LV dysfunction should prompt further investigations to evaluate for the underlying etiology.

Original languageEnglish (US)
Pages (from-to)207-217
Number of pages11
JournalHeart Failure Reviews
Volume18
Issue number2
DOIs
StatePublished - Mar 2013

Fingerprint

Dilated Cardiomyopathy
Cardiomyopathies
Obesity
Heart Failure
High Cardiac Output
Left Ventricular Dysfunction
Blood Volume
Hemodynamics

Keywords

  • Cardiomyopathy
  • Congestive heart failure
  • Dilated cardiomyopathy
  • Heart failure
  • Obesity
  • Systolic dysfunction
  • Systolic heart failure

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Obesity cardiomyopathy and systolic function : Obesity is not independently associated with dilated cardiomyopathy. / Khan, Muhammad Fahad; Movahed, Mohammad R.

In: Heart Failure Reviews, Vol. 18, No. 2, 03.2013, p. 207-217.

Research output: Contribution to journalArticle

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