Obesity in adolescence is associated with left ventricular hypertrophy and hypertension

Mohammad R Movahed, Sharon Bates, Deborah Strootman, Sudhakar Sattur

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Obesity is a risk factor for hypertension (HTN) and left ventricular hypertrophy (LVH). However, the association between obesity, HTN or LVH in adolescents has not been studied in a large population. Method: Utilizing a database of screening echocardiograms, we assessed for the presence of LVH and HTN (defined as systolic blood pressure (SBP) > 140 mmHg or diastolic blood pressure (DBP) > 90 mmHg) in obese adolescents (BMI > 30) using univariate and multivariate analysis. Results: A total of 2072 subjects were identified between the ages of 13-19 years. LVH was significantly more prevalent in obese subjects (47/166 [28.3%] vs. nonobese subjects (99/1612 [6.1%]) with a P-value of <0.001. Using multivariate analysis adjusting for age, gender and blood pressure, obesity remained strongly associated with the presence of LVH (OR 4.51, CI: 2.83-7.19, P < 0.001). Elevated SBP and DBP were also strongly associated with obesity. SBP > 140 was present in 38% of obese subjects (54/142) versus 12.7% of nonobese subjects (172/1, 353). DBP > 90 was present in 10.6% of obese subjects (15/141) of versus 3.1% of nonobese subjects (42/1352). After adjustment for age, gender and LVH, obesity remained independently associated with HTN (for SBP > 140, OR 2.24, CI: 1.46-3.45, P < 0.001, and for DBP > 90, OR 2.10, CI: 1.063-4.17, P = 0.03). Conclusion: Obese adolescents have a significantly higher prevalence of HTN and LVH. Our analysis suggests a direct negative effect of obesity on cardiovascular function starting early in teenage years.

Original languageEnglish (US)
Pages (from-to)150-153
Number of pages4
JournalEchocardiography
Volume28
Issue number2
DOIs
StatePublished - Feb 2011

Fingerprint

Pediatric Obesity
Left Ventricular Hypertrophy
Blood Pressure
Hypertension
Obesity
Multivariate Analysis
Databases
Population

Keywords

  • adolescents
  • echocardiography
  • hypertension
  • left ventricular hypertrophy
  • LVH
  • obese
  • overweight
  • screening
  • screening echocardiography

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Obesity in adolescence is associated with left ventricular hypertrophy and hypertension. / Movahed, Mohammad R; Bates, Sharon; Strootman, Deborah; Sattur, Sudhakar.

In: Echocardiography, Vol. 28, No. 2, 02.2011, p. 150-153.

Research output: Contribution to journalArticle

Movahed, Mohammad R ; Bates, Sharon ; Strootman, Deborah ; Sattur, Sudhakar. / Obesity in adolescence is associated with left ventricular hypertrophy and hypertension. In: Echocardiography. 2011 ; Vol. 28, No. 2. pp. 150-153.
@article{4a49de82872a4e3fb878c0766de22dda,
title = "Obesity in adolescence is associated with left ventricular hypertrophy and hypertension",
abstract = "Background: Obesity is a risk factor for hypertension (HTN) and left ventricular hypertrophy (LVH). However, the association between obesity, HTN or LVH in adolescents has not been studied in a large population. Method: Utilizing a database of screening echocardiograms, we assessed for the presence of LVH and HTN (defined as systolic blood pressure (SBP) > 140 mmHg or diastolic blood pressure (DBP) > 90 mmHg) in obese adolescents (BMI > 30) using univariate and multivariate analysis. Results: A total of 2072 subjects were identified between the ages of 13-19 years. LVH was significantly more prevalent in obese subjects (47/166 [28.3{\%}] vs. nonobese subjects (99/1612 [6.1{\%}]) with a P-value of <0.001. Using multivariate analysis adjusting for age, gender and blood pressure, obesity remained strongly associated with the presence of LVH (OR 4.51, CI: 2.83-7.19, P < 0.001). Elevated SBP and DBP were also strongly associated with obesity. SBP > 140 was present in 38{\%} of obese subjects (54/142) versus 12.7{\%} of nonobese subjects (172/1, 353). DBP > 90 was present in 10.6{\%} of obese subjects (15/141) of versus 3.1{\%} of nonobese subjects (42/1352). After adjustment for age, gender and LVH, obesity remained independently associated with HTN (for SBP > 140, OR 2.24, CI: 1.46-3.45, P < 0.001, and for DBP > 90, OR 2.10, CI: 1.063-4.17, P = 0.03). Conclusion: Obese adolescents have a significantly higher prevalence of HTN and LVH. Our analysis suggests a direct negative effect of obesity on cardiovascular function starting early in teenage years.",
keywords = "adolescents, echocardiography, hypertension, left ventricular hypertrophy, LVH, obese, overweight, screening, screening echocardiography",
author = "Movahed, {Mohammad R} and Sharon Bates and Deborah Strootman and Sudhakar Sattur",
year = "2011",
month = "2",
doi = "10.1111/j.1540-8175.2010.01289.x",
language = "English (US)",
volume = "28",
pages = "150--153",
journal = "Echocardiography",
issn = "0742-2822",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Obesity in adolescence is associated with left ventricular hypertrophy and hypertension

AU - Movahed, Mohammad R

AU - Bates, Sharon

AU - Strootman, Deborah

AU - Sattur, Sudhakar

PY - 2011/2

Y1 - 2011/2

N2 - Background: Obesity is a risk factor for hypertension (HTN) and left ventricular hypertrophy (LVH). However, the association between obesity, HTN or LVH in adolescents has not been studied in a large population. Method: Utilizing a database of screening echocardiograms, we assessed for the presence of LVH and HTN (defined as systolic blood pressure (SBP) > 140 mmHg or diastolic blood pressure (DBP) > 90 mmHg) in obese adolescents (BMI > 30) using univariate and multivariate analysis. Results: A total of 2072 subjects were identified between the ages of 13-19 years. LVH was significantly more prevalent in obese subjects (47/166 [28.3%] vs. nonobese subjects (99/1612 [6.1%]) with a P-value of <0.001. Using multivariate analysis adjusting for age, gender and blood pressure, obesity remained strongly associated with the presence of LVH (OR 4.51, CI: 2.83-7.19, P < 0.001). Elevated SBP and DBP were also strongly associated with obesity. SBP > 140 was present in 38% of obese subjects (54/142) versus 12.7% of nonobese subjects (172/1, 353). DBP > 90 was present in 10.6% of obese subjects (15/141) of versus 3.1% of nonobese subjects (42/1352). After adjustment for age, gender and LVH, obesity remained independently associated with HTN (for SBP > 140, OR 2.24, CI: 1.46-3.45, P < 0.001, and for DBP > 90, OR 2.10, CI: 1.063-4.17, P = 0.03). Conclusion: Obese adolescents have a significantly higher prevalence of HTN and LVH. Our analysis suggests a direct negative effect of obesity on cardiovascular function starting early in teenage years.

AB - Background: Obesity is a risk factor for hypertension (HTN) and left ventricular hypertrophy (LVH). However, the association between obesity, HTN or LVH in adolescents has not been studied in a large population. Method: Utilizing a database of screening echocardiograms, we assessed for the presence of LVH and HTN (defined as systolic blood pressure (SBP) > 140 mmHg or diastolic blood pressure (DBP) > 90 mmHg) in obese adolescents (BMI > 30) using univariate and multivariate analysis. Results: A total of 2072 subjects were identified between the ages of 13-19 years. LVH was significantly more prevalent in obese subjects (47/166 [28.3%] vs. nonobese subjects (99/1612 [6.1%]) with a P-value of <0.001. Using multivariate analysis adjusting for age, gender and blood pressure, obesity remained strongly associated with the presence of LVH (OR 4.51, CI: 2.83-7.19, P < 0.001). Elevated SBP and DBP were also strongly associated with obesity. SBP > 140 was present in 38% of obese subjects (54/142) versus 12.7% of nonobese subjects (172/1, 353). DBP > 90 was present in 10.6% of obese subjects (15/141) of versus 3.1% of nonobese subjects (42/1352). After adjustment for age, gender and LVH, obesity remained independently associated with HTN (for SBP > 140, OR 2.24, CI: 1.46-3.45, P < 0.001, and for DBP > 90, OR 2.10, CI: 1.063-4.17, P = 0.03). Conclusion: Obese adolescents have a significantly higher prevalence of HTN and LVH. Our analysis suggests a direct negative effect of obesity on cardiovascular function starting early in teenage years.

KW - adolescents

KW - echocardiography

KW - hypertension

KW - left ventricular hypertrophy

KW - LVH

KW - obese

KW - overweight

KW - screening

KW - screening echocardiography

UR - http://www.scopus.com/inward/record.url?scp=79551547811&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79551547811&partnerID=8YFLogxK

U2 - 10.1111/j.1540-8175.2010.01289.x

DO - 10.1111/j.1540-8175.2010.01289.x

M3 - Article

C2 - 21276070

AN - SCOPUS:79551547811

VL - 28

SP - 150

EP - 153

JO - Echocardiography

JF - Echocardiography

SN - 0742-2822

IS - 2

ER -