Abstract
A side-viewing, 2.3-mm diameter oblique incidence reflectometry endoscope has been designed to obtain optical property measurements of turbid samples. Light from a single-mode fiber is relayed obliquely onto the tissue with a gradient index lens-based distal optics assembly and the resulting diffuse reflectance profile is imaged and collected with a 30,000 element, 0.72 mm clear aperture fiber bundle. Sampling the diffuse reflectance in two-dimensions allows for fitting of the reflected intensity profile to a well-known theoretical model, permitting the extraction of both absorption and reduced scattering coefficients of the tissue sample. Models and measurements of the endoscopic imaging system are presented in tissue phantoms and in vivo mouse colon, verifying the endoscope's capabilities to accurately measure effective attenuation coefficient and differentiate diseased from normal colon.
| Original language | English (US) |
|---|---|
| Article number | 067002 |
| Journal | Journal of Biomedical Optics |
| Volume | 19 |
| Issue number | 6 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- absorption coefficient
- colon.
- endoscope
- gastrointestinal
- gradient-index
- oblique incidence reflectometry
- reduced scattering coefficient
- tissue optical properties
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
- Medicine(all)
Cite this
Oblique incidence reflectometry : Optical models and measurements using a side-viewing gradient index lens-based endoscopic imaging system. / Wall, R. Andrew; Barton, Jennifer K.
In: Journal of Biomedical Optics, Vol. 19, No. 6, 067002, 2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Oblique incidence reflectometry
T2 - Optical models and measurements using a side-viewing gradient index lens-based endoscopic imaging system
AU - Wall, R. Andrew
AU - Barton, Jennifer K
PY - 2014
Y1 - 2014
N2 - A side-viewing, 2.3-mm diameter oblique incidence reflectometry endoscope has been designed to obtain optical property measurements of turbid samples. Light from a single-mode fiber is relayed obliquely onto the tissue with a gradient index lens-based distal optics assembly and the resulting diffuse reflectance profile is imaged and collected with a 30,000 element, 0.72 mm clear aperture fiber bundle. Sampling the diffuse reflectance in two-dimensions allows for fitting of the reflected intensity profile to a well-known theoretical model, permitting the extraction of both absorption and reduced scattering coefficients of the tissue sample. Models and measurements of the endoscopic imaging system are presented in tissue phantoms and in vivo mouse colon, verifying the endoscope's capabilities to accurately measure effective attenuation coefficient and differentiate diseased from normal colon.
AB - A side-viewing, 2.3-mm diameter oblique incidence reflectometry endoscope has been designed to obtain optical property measurements of turbid samples. Light from a single-mode fiber is relayed obliquely onto the tissue with a gradient index lens-based distal optics assembly and the resulting diffuse reflectance profile is imaged and collected with a 30,000 element, 0.72 mm clear aperture fiber bundle. Sampling the diffuse reflectance in two-dimensions allows for fitting of the reflected intensity profile to a well-known theoretical model, permitting the extraction of both absorption and reduced scattering coefficients of the tissue sample. Models and measurements of the endoscopic imaging system are presented in tissue phantoms and in vivo mouse colon, verifying the endoscope's capabilities to accurately measure effective attenuation coefficient and differentiate diseased from normal colon.
KW - absorption coefficient
KW - colon.
KW - endoscope
KW - gastrointestinal
KW - gradient-index
KW - oblique incidence reflectometry
KW - reduced scattering coefficient
KW - tissue optical properties
UR - http://www.scopus.com/inward/record.url?scp=84902097100&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84902097100&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.19.6.067002
DO - 10.1117/1.JBO.19.6.067002
M3 - Article
C2 - 24892970
AN - SCOPUS:84902097100
VL - 19
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
SN - 1083-3668
IS - 6
M1 - 067002
ER -