Oblique incidence reflectometry: Optical models and measurements using a side-viewing gradient index lens-based endoscopic imaging system

R. Andrew Wall, Jennifer K Barton

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A side-viewing, 2.3-mm diameter oblique incidence reflectometry endoscope has been designed to obtain optical property measurements of turbid samples. Light from a single-mode fiber is relayed obliquely onto the tissue with a gradient index lens-based distal optics assembly and the resulting diffuse reflectance profile is imaged and collected with a 30,000 element, 0.72 mm clear aperture fiber bundle. Sampling the diffuse reflectance in two-dimensions allows for fitting of the reflected intensity profile to a well-known theoretical model, permitting the extraction of both absorption and reduced scattering coefficients of the tissue sample. Models and measurements of the endoscopic imaging system are presented in tissue phantoms and in vivo mouse colon, verifying the endoscope's capabilities to accurately measure effective attenuation coefficient and differentiate diseased from normal colon.

Original languageEnglish (US)
Article number067002
JournalJournal of Biomedical Optics
Volume19
Issue number6
DOIs
StatePublished - 2014

Fingerprint

Imaging systems
Lenses
endoscopes
Endoscopy
incidence
Endoscopes
lenses
Tissue
gradients
Incidence
Colon
reflectance
fibers
scattering coefficients
attenuation coefficients
Single mode fibers
profiles
bundles
mice
Optics

Keywords

  • absorption coefficient
  • colon.
  • endoscope
  • gastrointestinal
  • gradient-index
  • oblique incidence reflectometry
  • reduced scattering coefficient
  • tissue optical properties

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Medicine(all)

Cite this

@article{efe808ca75cf495e8e7a8840f85f873b,
title = "Oblique incidence reflectometry: Optical models and measurements using a side-viewing gradient index lens-based endoscopic imaging system",
abstract = "A side-viewing, 2.3-mm diameter oblique incidence reflectometry endoscope has been designed to obtain optical property measurements of turbid samples. Light from a single-mode fiber is relayed obliquely onto the tissue with a gradient index lens-based distal optics assembly and the resulting diffuse reflectance profile is imaged and collected with a 30,000 element, 0.72 mm clear aperture fiber bundle. Sampling the diffuse reflectance in two-dimensions allows for fitting of the reflected intensity profile to a well-known theoretical model, permitting the extraction of both absorption and reduced scattering coefficients of the tissue sample. Models and measurements of the endoscopic imaging system are presented in tissue phantoms and in vivo mouse colon, verifying the endoscope's capabilities to accurately measure effective attenuation coefficient and differentiate diseased from normal colon.",
keywords = "absorption coefficient, colon., endoscope, gastrointestinal, gradient-index, oblique incidence reflectometry, reduced scattering coefficient, tissue optical properties",
author = "Wall, {R. Andrew} and Barton, {Jennifer K}",
year = "2014",
doi = "10.1117/1.JBO.19.6.067002",
language = "English (US)",
volume = "19",
journal = "Journal of Biomedical Optics",
issn = "1083-3668",
publisher = "SPIE",
number = "6",

}

TY - JOUR

T1 - Oblique incidence reflectometry

T2 - Optical models and measurements using a side-viewing gradient index lens-based endoscopic imaging system

AU - Wall, R. Andrew

AU - Barton, Jennifer K

PY - 2014

Y1 - 2014

N2 - A side-viewing, 2.3-mm diameter oblique incidence reflectometry endoscope has been designed to obtain optical property measurements of turbid samples. Light from a single-mode fiber is relayed obliquely onto the tissue with a gradient index lens-based distal optics assembly and the resulting diffuse reflectance profile is imaged and collected with a 30,000 element, 0.72 mm clear aperture fiber bundle. Sampling the diffuse reflectance in two-dimensions allows for fitting of the reflected intensity profile to a well-known theoretical model, permitting the extraction of both absorption and reduced scattering coefficients of the tissue sample. Models and measurements of the endoscopic imaging system are presented in tissue phantoms and in vivo mouse colon, verifying the endoscope's capabilities to accurately measure effective attenuation coefficient and differentiate diseased from normal colon.

AB - A side-viewing, 2.3-mm diameter oblique incidence reflectometry endoscope has been designed to obtain optical property measurements of turbid samples. Light from a single-mode fiber is relayed obliquely onto the tissue with a gradient index lens-based distal optics assembly and the resulting diffuse reflectance profile is imaged and collected with a 30,000 element, 0.72 mm clear aperture fiber bundle. Sampling the diffuse reflectance in two-dimensions allows for fitting of the reflected intensity profile to a well-known theoretical model, permitting the extraction of both absorption and reduced scattering coefficients of the tissue sample. Models and measurements of the endoscopic imaging system are presented in tissue phantoms and in vivo mouse colon, verifying the endoscope's capabilities to accurately measure effective attenuation coefficient and differentiate diseased from normal colon.

KW - absorption coefficient

KW - colon.

KW - endoscope

KW - gastrointestinal

KW - gradient-index

KW - oblique incidence reflectometry

KW - reduced scattering coefficient

KW - tissue optical properties

UR - http://www.scopus.com/inward/record.url?scp=84902097100&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84902097100&partnerID=8YFLogxK

U2 - 10.1117/1.JBO.19.6.067002

DO - 10.1117/1.JBO.19.6.067002

M3 - Article

C2 - 24892970

AN - SCOPUS:84902097100

VL - 19

JO - Journal of Biomedical Optics

JF - Journal of Biomedical Optics

SN - 1083-3668

IS - 6

M1 - 067002

ER -