Obstructive sleep apnea - pathogenesis and treatment

Mark H. Gotfried, Stuart F Quan

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Obstructive sleep apnea is characterized by repetitive episodes of upper airway occlusion occurring during sleep. The clinical syndrome appears to occur in individuals who exhibit instability of ventilatory drive during light NREM sleep, and who also have subtle or overt abnormalities of their upper airway. The most prominent clinical manifestations are daytime hypersomnolence and loud snoring. Bypassing the area of obstruction with a tracheostomy results in an improvement in clinical symptoms, but cosmetic and medical problems associated with the procedure limit patient acceptance. Recently, protriptyline, nasal continuous positive airway pressure, and uvulopalatopharyngoplasty have been introduced as alternative treatment modalities in obstructive sleep apnea patients. Although the data are still preliminary, these less invasive modes of treatment are promising and might be considered in non life-threatening obstructive sleep apnea before resorting to tracheostomy.

Original languageEnglish (US)
Pages (from-to)1-13
Number of pages13
JournalLung
Volume162
Issue number1
DOIs
StatePublished - Dec 1984

Fingerprint

Obstructive Sleep Apnea
Tracheostomy
Sleep
Protriptyline
Disorders of Excessive Somnolence
Snoring
Continuous Positive Airway Pressure
Cosmetics
Therapeutics
Light

Keywords

  • Airway obstruction
  • Hypersomnolence
  • Sleep
  • Sleep apnea

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Physiology

Cite this

Obstructive sleep apnea - pathogenesis and treatment. / Gotfried, Mark H.; Quan, Stuart F.

In: Lung, Vol. 162, No. 1, 12.1984, p. 1-13.

Research output: Contribution to journalArticle

Gotfried, Mark H. ; Quan, Stuart F. / Obstructive sleep apnea - pathogenesis and treatment. In: Lung. 1984 ; Vol. 162, No. 1. pp. 1-13.
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