Olfactory Mucosa: Composition, Enzymatic Localization, and Metabolism

Xinxin Ding, Fang Xie

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

This chapter examines the basic structure and cell types of the olfactory mucosa, and then focuses primarily on the enzymatic capacity of the tissue. The anatomic characteristics generally common to all species are outlined and followed by a brief discussion of interspecies variability in the magnitude, localization, or occurrence of these characteristics. The identity and localization of nasal enzymes and their metabolic capacities are compared across several species. The potential for these enzymes to modulate the toxicity of xenobiotics and to influence tissue function, including homeostasis and odor signal detection, is discussed. The chapter describes the complexity in the composition and regulation of the major known biotransformation enzymes in the olfactory mucosa. Additionally, it discusses various physiological and pathological processes in which nasal metabolic activity is thought to play a role.

Original languageEnglish (US)
Title of host publicationHandbook of Olfaction and Gustation
Subtitle of host publicationThird Edition
PublisherWiley-Blackwell
Pages63-92
Number of pages30
ISBN (Electronic)9781118971758
ISBN (Print)9781118139226
DOIs
Publication statusPublished - Jun 4 2015
Externally publishedYes

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Keywords

  • Biotransformation enzymes
  • Enzymatic localization
  • Homeostasis
  • Inhaled toxicants
  • Nasal enzymes
  • Nasal xenobiotic metabolism
  • Odor signal detection
  • Olfactory mucosa

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Ding, X., & Xie, F. (2015). Olfactory Mucosa: Composition, Enzymatic Localization, and Metabolism. In Handbook of Olfaction and Gustation: Third Edition (pp. 63-92). Wiley-Blackwell. https://doi.org/10.1002/9781118971758.ch3