Oligohydramnios sequence and renal tubular malformation associated with maternal enalapril use

Christopher M Cunniff, Kenneth Lyons Jones, Julia Phillipson, Kurt Benirschke, Sandra Short, Joseph Wujek

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

We present the case of a child who died of pulmonary hypoplasia as a result of the oligohydramnios sequence. The mother was taking enalapril, as well as propranolol and hydrochlorothiazide, for treatment of hypertension associated with systemic lupus erythematosus. Autopsy examination revealed severe renal tubular malformation. Correlation of animal data with previous case reports of neonatal anuria in association with maternal angiotensin converting enzyme inhibitors suggests that these agents may have a deleterious effect on fetal renal development and general well-being.

Original languageEnglish (US)
Pages (from-to)187-189
Number of pages3
JournalAmerican Journal of Obstetrics and Gynecology
Volume162
Issue number1
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Oligohydramnios
Enalapril
Mothers
Anuria
Kidney
Hydrochlorothiazide
Fetal Development
Angiotensin-Converting Enzyme Inhibitors
Propranolol
Systemic Lupus Erythematosus
Autopsy
Hypertension
Lung
Therapeutics

Keywords

  • angiotensin converting enzyme inhibitors
  • captopril
  • Enalapril
  • renal dysgenesis

ASJC Scopus subject areas

  • Medicine(all)
  • Obstetrics and Gynecology

Cite this

Oligohydramnios sequence and renal tubular malformation associated with maternal enalapril use. / Cunniff, Christopher M; Jones, Kenneth Lyons; Phillipson, Julia; Benirschke, Kurt; Short, Sandra; Wujek, Joseph.

In: American Journal of Obstetrics and Gynecology, Vol. 162, No. 1, 1990, p. 187-189.

Research output: Contribution to journalArticle

Cunniff, Christopher M ; Jones, Kenneth Lyons ; Phillipson, Julia ; Benirschke, Kurt ; Short, Sandra ; Wujek, Joseph. / Oligohydramnios sequence and renal tubular malformation associated with maternal enalapril use. In: American Journal of Obstetrics and Gynecology. 1990 ; Vol. 162, No. 1. pp. 187-189.
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