On DNA computers controlling gene expression levels

Olgica Milenkovic, Navin Kashyap, Bane V Vasic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

The area of bio-molecular computing has recently witnessed a major paradigm shift. Rather then being used only as simple calculating units capable of solving hard combinatorial or numerical problems, DNA computers are increasingly becoming more tailored to operate like intelligent biological machines with unprecedented potentials. One example of applying DNA computers in such a new setting is in the area of logical control of gene expression levels. For this purpose, DNA computers are designed in such a way as to be able to diagnose some forms of cancer-related irregularities in a cell and release biological strands acting as inhibitors or activators of certain sets of genes. Such a control action can also be seen as a form of intra-cell cancer therapy, although it may also have other, more varied, purposes and goals. There are several important problems in the area of coding and network theory that arise in the context of developing DNA computers for controlling gene expressions. The two most important issues are that of minimizing diagnostics failure and of increasing the computational reliability of the system. The first question is intimately related to analyzing the operational principles of networks of gene interactions, while the second is concerned with relating combinatorial characteristics of single-stranded DNA sequences to their hybridization affinities and secondary structures. In this paper, we will describe the state-of-the-art results and present some new relevant combinatorial and coding theoretic problems in this area.

Original languageEnglish (US)
Title of host publicationProceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05
Pages1770-1775
Number of pages6
Volume2005
DOIs
StatePublished - 2005
Event44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05 - Seville, Spain
Duration: Dec 12 2005Dec 15 2005

Other

Other44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05
CountrySpain
CitySeville
Period12/12/0512/15/05

Fingerprint

Gene expression
DNA
Genes
DNA sequences
Circuit theory

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Milenkovic, O., Kashyap, N., & Vasic, B. V. (2005). On DNA computers controlling gene expression levels. In Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05 (Vol. 2005, pp. 1770-1775). [1582416] https://doi.org/10.1109/CDC.2005.1582416

On DNA computers controlling gene expression levels. / Milenkovic, Olgica; Kashyap, Navin; Vasic, Bane V.

Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05. Vol. 2005 2005. p. 1770-1775 1582416.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Milenkovic, O, Kashyap, N & Vasic, BV 2005, On DNA computers controlling gene expression levels. in Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05. vol. 2005, 1582416, pp. 1770-1775, 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05, Seville, Spain, 12/12/05. https://doi.org/10.1109/CDC.2005.1582416
Milenkovic O, Kashyap N, Vasic BV. On DNA computers controlling gene expression levels. In Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05. Vol. 2005. 2005. p. 1770-1775. 1582416 https://doi.org/10.1109/CDC.2005.1582416
Milenkovic, Olgica ; Kashyap, Navin ; Vasic, Bane V. / On DNA computers controlling gene expression levels. Proceedings of the 44th IEEE Conference on Decision and Control, and the European Control Conference, CDC-ECC '05. Vol. 2005 2005. pp. 1770-1775
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