On the rate of genetic adaptation under natural selection

For a one locus n-allele genetic model of natural selection two theoretical predictions are obtained: first, that the non-equilibrium average fitness value, W(t) is always between the equilibrium value, W*, and W*-H(p_o, p*) t until finally W(t) = W* and, secondly, that the area bounded by W* and the curve W(t) is equal to H(p₀,p*), the entropy distance between initial (p₀) and equilibrium (p*) gene frequency distributions. The experimental observations corresponding to these predictions are discussed.