One-pot microwave assisted preparation of pyrazoloquinazolinone libraries

Thomas E. Vasquez, Thomas Nixey, Balan Chenera, Vijay Gore, Michael D. Bartberger, Yaxiong Sun, Christopher Hulme

Research output: Contribution to journalArticle

16 Scopus citations

Abstract

The novel solution-phase synthesis of an array of biologically relevant pyrazoloquinazolinones in a simple microwave driven one pot procedure is revelaed. Transformations are carried out in good to excellent yield by condensation of α-cyano-ketones and 2-hydrazino-benzoic acids. Subsequent microwave irradiation affords pyrazoloquinazolinones with six points of potential diversification. The protocol described represents a very attractive solution phase procedure for the rapid generation of arrays of such functionalized cores, further demonstrating the growing importance of economic and enabling complexity generating chemistries in the lead discovery arena.

Original languageEnglish (US)
Pages (from-to)161-164
Number of pages4
JournalMolecular Diversity
Volume7
Issue number2-4
DOIs
StatePublished - Dec 1 2003
Externally publishedYes

Keywords

  • Library
  • Microwave
  • Pyrazoloquinazolinone

ASJC Scopus subject areas

  • Catalysis
  • Information Systems
  • Molecular Biology
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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