One-Pot Two-Step Multicomponent Process of Indole and Other Nitrogenous Heterocycles or Amines toward α-Oxo-acetamidines

Guillermo Martinez-Ariza, Nicholas McConnell, Christopher Hulme

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

A cesium carbonate promoted three-component reaction of N-H containing heterocycles, primary or secondary amines, arylglyoxaldehydes, and anilines is reported. The key step involves a tandem sequence of N-1 addition of a heterocycle or an amine to preformed α-iminoketones, followed by an air- or oxygen-mediated oxidation to form α-oxo-acetamidines. The scope of the reaction is enticingly broad, and this novel methodology is applied toward the synthesis of various polycyclic heterocycles.

Original languageEnglish (US)
Pages (from-to)1864-1867
Number of pages4
JournalOrganic Letters
Volume18
Issue number8
DOIs
StatePublished - Apr 15 2016

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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