Thieno[2,3-d]pyrimidin-4(3H)-ones are important pharmacophores that have previously required a three-step synthesis with two chromatography steps. We herein report a green approach to the synthesis of this pharmacologically important class of compounds via a catalytic four-component reaction using a ketone, ethyl cyanoacetate, S8, and formamide. The reported reaction is characterized by step economy, reduced catalyst loading, and easy purification.
- Catalytic multicomponent reaction
- green chemistry
- Thieno[2,3- d]pyrimidin-4(3 H)-ones
ASJC Scopus subject areas
- Environmental Chemistry
- Chemical Engineering(all)
- Renewable Energy, Sustainability and the Environment