One-Step Synthesis of Thieno[2,3- d]pyrimidin-4(3 H)-ones via a Catalytic Four-Component Reaction of Ketones, Ethyl Cyanoacetate, S 8 , and Formamide

Taoda Shi, Lynn Kaneko, Michael Sandino, Ryan Busse, Mae Zhang, Damian Mason, Jason Machulis, Andrew J. Ambrose, Donna D. Zhang, Eli Chapman

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Thieno[2,3-d]pyrimidin-4(3H)-ones are important pharmacophores that have previously required a three-step synthesis with two chromatography steps. We herein report a green approach to the synthesis of this pharmacologically important class of compounds via a catalytic four-component reaction using a ketone, ethyl cyanoacetate, S 8 , and formamide. The reported reaction is characterized by step economy, reduced catalyst loading, and easy purification.

Original languageEnglish (US)
Pages (from-to)1524-1528
Number of pages5
JournalACS Sustainable Chemistry and Engineering
Volume7
Issue number1
DOIs
StatePublished - Jan 7 2019

Keywords

  • Catalytic multicomponent reaction
  • Thieno[2,3- d]pyrimidin-4(3 H)-ones
  • green chemistry

ASJC Scopus subject areas

  • Chemistry(all)
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Renewable Energy, Sustainability and the Environment

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