Ontogeny and molecular characterization of estrogen receptors in the hippocampus

Robert J Handa, Richard H. Price, Cheryl A. Butler, Derek T. Solum

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The actions of estrogen are thought to be exerted via the estrogen receptor (ER), of which there are two isoforms, a and β. ERα and ERβ are intracellular receptors that belong to a large nuclear receptor superfamily of proteins. Estrogen receptors function directly as ligand-dependent transcription factors that regulate the synthesis of specific RNAs and proteins. The estrogen receptors are similar to most other steroid hormone receptors in that they exhibit a variable N-terminal region, a short and well-conserved cysteinerich central DNA binding domain, and a relatively well-conserved ligand binding carboxyl-terminal half.1 The carboxyl terminal domain is both structurally and functionally complex.

Original languageEnglish (US)
Title of host publicationNeuroplasticity, Development, and Steroid Hormone Action
PublisherCRC Press
Pages371-391
Number of pages21
ISBN (Electronic)9781420041194
ISBN (Print)084930962X, 9780849309625
StatePublished - Jan 1 2001
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)
  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Handa, R. J., Price, R. H., Butler, C. A., & Solum, D. T. (2001). Ontogeny and molecular characterization of estrogen receptors in the hippocampus. In Neuroplasticity, Development, and Steroid Hormone Action (pp. 371-391). CRC Press.