Ontogeny of mammalian cardiac α1-adrenergic receptors

Shizuo Yamada, Henry I. Yamamura, William S. Roeske

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

We find similar number of α1-adrenergic receptors in fetal mouse hearts of 15–20 day gestational age as compared to adult mouse hearts, and a significantly greater number of α1-adrenoceptors in the early neonate (7–21 days) hearts. Cardiac norepinephrine (NE) concentrations were extremely low inthe fetus and increased continuously after birth to reach adult levels at about 21 days of age. Te cardiac α1-adrenergic receptors prior to the development of a presynaptic component (NE) and show a dramatic increase in density without a change in affinity in the early neonate which then decrease with innervation.

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalEuropean Journal of Pharmacology
Volume68
Issue number2
DOIs
StatePublished - 1980

Keywords

  • Cardiac α-adrenergic receptor
  • Development
  • Norepinephrine levels
  • [H]WB4101 binding

ASJC Scopus subject areas

  • Pharmacology

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