Ontogeny of mammalian cardiac α1-adrenergic recpeptors

S. Yamada, H. I. Yamamura, William R Roeske

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

We find a similar number of α1-adrenergic receptors in fetal mouse hearts of 15-20 day gestational age as compared to adults mouse hearts, and a significantly greater number of α1-adrenoceptors in the early neonate (7-21 days) hearts. Cardiac norepinephrine (NE) concentrations were extremely low in the fetus and increased continuously after birth to reach adult levels at about 21 days of age. The cardiac α1-adrenergic receptors mature prior to the development of a presynaptic component (NE) and show a dramatic increase in density without a change in affinity in the early neonate which then decreases with innervation.

Original languageEnglish (US)
Pages (from-to)217-221
Number of pages5
JournalEuropean Journal of Pharmacology
Volume68
Issue number2
StatePublished - 1980

Fingerprint

Adrenergic Agents
Adrenergic Receptors
Norepinephrine
Fetal Heart
Gestational Age
Fetus
Parturition

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Ontogeny of mammalian cardiac α1-adrenergic recpeptors. / Yamada, S.; Yamamura, H. I.; Roeske, William R.

In: European Journal of Pharmacology, Vol. 68, No. 2, 1980, p. 217-221.

Research output: Contribution to journalArticle

Yamada, S. ; Yamamura, H. I. ; Roeske, William R. / Ontogeny of mammalian cardiac α1-adrenergic recpeptors. In: European Journal of Pharmacology. 1980 ; Vol. 68, No. 2. pp. 217-221.
@article{2530a5ba1d894441945b48be10565d9e,
title = "Ontogeny of mammalian cardiac α1-adrenergic recpeptors",
abstract = "We find a similar number of α1-adrenergic receptors in fetal mouse hearts of 15-20 day gestational age as compared to adults mouse hearts, and a significantly greater number of α1-adrenoceptors in the early neonate (7-21 days) hearts. Cardiac norepinephrine (NE) concentrations were extremely low in the fetus and increased continuously after birth to reach adult levels at about 21 days of age. The cardiac α1-adrenergic receptors mature prior to the development of a presynaptic component (NE) and show a dramatic increase in density without a change in affinity in the early neonate which then decreases with innervation.",
author = "S. Yamada and Yamamura, {H. I.} and Roeske, {William R}",
year = "1980",
language = "English (US)",
volume = "68",
pages = "217--221",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Ontogeny of mammalian cardiac α1-adrenergic recpeptors

AU - Yamada, S.

AU - Yamamura, H. I.

AU - Roeske, William R

PY - 1980

Y1 - 1980

N2 - We find a similar number of α1-adrenergic receptors in fetal mouse hearts of 15-20 day gestational age as compared to adults mouse hearts, and a significantly greater number of α1-adrenoceptors in the early neonate (7-21 days) hearts. Cardiac norepinephrine (NE) concentrations were extremely low in the fetus and increased continuously after birth to reach adult levels at about 21 days of age. The cardiac α1-adrenergic receptors mature prior to the development of a presynaptic component (NE) and show a dramatic increase in density without a change in affinity in the early neonate which then decreases with innervation.

AB - We find a similar number of α1-adrenergic receptors in fetal mouse hearts of 15-20 day gestational age as compared to adults mouse hearts, and a significantly greater number of α1-adrenoceptors in the early neonate (7-21 days) hearts. Cardiac norepinephrine (NE) concentrations were extremely low in the fetus and increased continuously after birth to reach adult levels at about 21 days of age. The cardiac α1-adrenergic receptors mature prior to the development of a presynaptic component (NE) and show a dramatic increase in density without a change in affinity in the early neonate which then decreases with innervation.

UR - http://www.scopus.com/inward/record.url?scp=0019147939&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019147939&partnerID=8YFLogxK

M3 - Article

VL - 68

SP - 217

EP - 221

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 2

ER -