Opening Pandoras jar: A primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders

Rajesh Khanna, Sarah M. Wilson, Joel M. Brittain, Jill Weimer, Rukhsana Sultana, Allan Butterfield, Kenneth Hensley

Research output: Contribution to journalArticle

63 Citations (Scopus)

Abstract

CRMP2, also known as DPYSL2/DRP2, Unc-33, Ulip or TUC2, is a cytosolic phosphoprotein that mediates axon/dendrite specification and axonal growth. Mapping the CRMP2 interactome has revealed previously unappreciated functions subserved by this protein. Together with its canonical roles in neurite growth and retraction and kinesin-dependent axonal transport, it is now known that CRMP2 interacts with numerous binding partners to affect microtubule dynamics; protein endocytosis and vesicular cycling, synaptic assembly, calcium channel regulation and neurotransmitter release. CRMP2 signaling is regulated by post-translational modifications, including glycosylation, oxidation, proteolysis and phosphorylation; the latter being a fulcrum of CRMP2 functions. Here, the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders are discussed and evidence is presented for therapeutic strategies targeting CRMP2 functions.

Original languageEnglish (US)
Pages (from-to)749-771
Number of pages23
JournalFuture Neurology
Volume7
Issue number6
DOIs
StatePublished - Nov 2012
Externally publishedYes

Fingerprint

Motor Neurons
Sensory Receptor Cells
Kinesin
Axonal Transport
Phosphoproteins
Neurites
Calcium Channels
Post Translational Protein Processing
Growth
Dendrites
Endocytosis
Glycosylation
Microtubules
Proteolysis
Neurotransmitter Agents
Axons
Proteins
Phosphorylation
Therapeutics

Keywords

  • Alzheimers disease
  • amyotrophic lateral sclerosis
  • axon elongation
  • CRMP2
  • CRMP2 hyperphosphorylation
  • CRMP2/CLN6/KLC4 signaling complex
  • excitotoxicity
  • multiple sclerosis
  • neuropathic pain
  • oxidative damage

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Opening Pandoras jar : A primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders. / Khanna, Rajesh; Wilson, Sarah M.; Brittain, Joel M.; Weimer, Jill; Sultana, Rukhsana; Butterfield, Allan; Hensley, Kenneth.

In: Future Neurology, Vol. 7, No. 6, 11.2012, p. 749-771.

Research output: Contribution to journalArticle

Khanna, Rajesh ; Wilson, Sarah M. ; Brittain, Joel M. ; Weimer, Jill ; Sultana, Rukhsana ; Butterfield, Allan ; Hensley, Kenneth. / Opening Pandoras jar : A primer on the putative roles of CRMP2 in a panoply of neurodegenerative, sensory and motor neuron, and central disorders. In: Future Neurology. 2012 ; Vol. 7, No. 6. pp. 749-771.
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