Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons

W. Zieglgänsberger, Edward D French, G. R. Seggins, F. E. Bloom

Research output: Contribution to journalArticle

461 Citations (Scopus)

Abstract

The atypical excitation by opiates and opioid peptides of hippocampal pyramidal cells can be antagonized by iontophoresis of naloxone, the γ-aminobutyric acid antagonist bicuculline, or magnesium ion. The recurrent inhibition of these cells evoked by transcallosal stimulation of the contralateral hippocampus is blocked by enkephalin but only shortened by acetylcholine. The results suggest that the opioids excite pyramidal neurons indirectly by inhibition of neighboring inhibitory interneurons (probably containing γ-aminobutyric acid). This mechanism may be pertinent to the electrographic signs of addictive drugs.

Original languageEnglish (US)
Pages (from-to)415-417
Number of pages3
JournalScience
Volume205
Issue number4404
StatePublished - 1979
Externally publishedYes

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Aminobutyrates
Opioid Peptides
Pyramidal Cells
Interneurons
Iontophoresis
Bicuculline
Enkephalins
Naloxone
Magnesium
Opioid Analgesics
Acetylcholine
Hippocampus
Ions
Pharmaceutical Preparations

ASJC Scopus subject areas

  • General

Cite this

Zieglgänsberger, W., French, E. D., Seggins, G. R., & Bloom, F. E. (1979). Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons. Science, 205(4404), 415-417.

Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons. / Zieglgänsberger, W.; French, Edward D; Seggins, G. R.; Bloom, F. E.

In: Science, Vol. 205, No. 4404, 1979, p. 415-417.

Research output: Contribution to journalArticle

Zieglgänsberger, W, French, ED, Seggins, GR & Bloom, FE 1979, 'Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons', Science, vol. 205, no. 4404, pp. 415-417.
Zieglgänsberger, W. ; French, Edward D ; Seggins, G. R. ; Bloom, F. E. / Opioid peptides may excite hippocampal pyramidal neurons by inhibiting adjacent inhibitory interneurons. In: Science. 1979 ; Vol. 205, No. 4404. pp. 415-417.
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