Opposing morphogenetic defects on dendrites and Mossy fibers of dentate granular neurons in CRMP3-deficient mice

Tam T. Quach, Nathalie Auvergnon, Rajesh Khanna, Marie Françoise Belin, Papachan E. Kolattukudy, Jérome Honnorat, Anne Marie Duchemin

Research output: Contribution to journalArticle

Abstract

Collapsin response mediator proteins (CRMPs) are highly expressed in the brain during early postnatal development and continue to be present in specific regions into adulthood, especially in areas with extensive neuronal plasticity including the hippocampus. They are found in the axons and dendrites of neurons wherein they contribute to specific signaling mechanisms involved in the regulation of axonal and dendritic development/maintenance. We previously identified CRMP3’s role on the morphology of hippocampal CA1 pyramidal dendrites and hippocampus-dependent functions. Our focus here was to further analyze its role in the dentate gyrus where it is highly expressed during development and in adults. On the basis of our new findings, it appears that CRMP3 has critical roles both in axonal and dendritic morphogenesis of dentate granular neurons. In CRMP3-deficient mice, the dendrites become dystrophic while the infrapyramidal bundle of the mossy fiber shows aberrant extension into the stratum oriens of CA3. This axonal misguided projection of granular neurons suggests that the mossy fiber-CA3 synaptic transmission, important for the evoked propagation of the activity of the hippocampal trisynaptic circuitry, may be altered, whereas the dystrophic dendrites may impair the dynamic interactions with the entorhinal cortex, both expected to affect hippocampal function.

Original languageEnglish (US)
Article number196
JournalBrain Sciences
Volume8
Issue number11
DOIs
StatePublished - Nov 3 2018

Keywords

  • CA3
  • CRMP3
  • Dendrite
  • Dentate granule cells
  • Dentate gyrus development
  • Morphogenesis
  • Mossy fiber

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Opposing morphogenetic defects on dendrites and Mossy fibers of dentate granular neurons in CRMP3-deficient mice'. Together they form a unique fingerprint.

  • Cite this

    Quach, T. T., Auvergnon, N., Khanna, R., Belin, M. F., Kolattukudy, P. E., Honnorat, J., & Duchemin, A. M. (2018). Opposing morphogenetic defects on dendrites and Mossy fibers of dentate granular neurons in CRMP3-deficient mice. Brain Sciences, 8(11), [196]. https://doi.org/10.3390/brainsci8110196