Opposing morphogenetic defects on dendrites and Mossy fibers of dentate granular neurons in CRMP3-deficient mice

Tam T. Quach, Nathalie Auvergnon, Rajesh Khanna, Marie Françoise Belin, Papachan E. Kolattukudy, Jérome Honnorat, Anne Marie Duchemin

Research output: Contribution to journalArticle

Abstract

Collapsin response mediator proteins (CRMPs) are highly expressed in the brain during early postnatal development and continue to be present in specific regions into adulthood, especially in areas with extensive neuronal plasticity including the hippocampus. They are found in the axons and dendrites of neurons wherein they contribute to specific signaling mechanisms involved in the regulation of axonal and dendritic development/maintenance. We previously identified CRMP3’s role on the morphology of hippocampal CA1 pyramidal dendrites and hippocampus-dependent functions. Our focus here was to further analyze its role in the dentate gyrus where it is highly expressed during development and in adults. On the basis of our new findings, it appears that CRMP3 has critical roles both in axonal and dendritic morphogenesis of dentate granular neurons. In CRMP3-deficient mice, the dendrites become dystrophic while the infrapyramidal bundle of the mossy fiber shows aberrant extension into the stratum oriens of CA3. This axonal misguided projection of granular neurons suggests that the mossy fiber-CA3 synaptic transmission, important for the evoked propagation of the activity of the hippocampal trisynaptic circuitry, may be altered, whereas the dystrophic dendrites may impair the dynamic interactions with the entorhinal cortex, both expected to affect hippocampal function.

Original languageEnglish (US)
Article number196
JournalBrain Sciences
Volume8
Issue number11
DOIs
StatePublished - Nov 3 2018

Fingerprint

Dendrites
Neurons
Hippocampus
Semaphorin-3A
Entorhinal Cortex
Neuronal Plasticity
Dentate Gyrus
Morphogenesis
Synaptic Transmission
Axons
Maintenance
Brain
Proteins

Keywords

  • CA3
  • CRMP3
  • Dendrite
  • Dentate granule cells
  • Dentate gyrus development
  • Morphogenesis
  • Mossy fiber

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Quach, T. T., Auvergnon, N., Khanna, R., Belin, M. F., Kolattukudy, P. E., Honnorat, J., & Duchemin, A. M. (2018). Opposing morphogenetic defects on dendrites and Mossy fibers of dentate granular neurons in CRMP3-deficient mice. Brain Sciences, 8(11), [196]. https://doi.org/10.3390/brainsci8110196

Opposing morphogenetic defects on dendrites and Mossy fibers of dentate granular neurons in CRMP3-deficient mice. / Quach, Tam T.; Auvergnon, Nathalie; Khanna, Rajesh; Belin, Marie Françoise; Kolattukudy, Papachan E.; Honnorat, Jérome; Duchemin, Anne Marie.

In: Brain Sciences, Vol. 8, No. 11, 196, 03.11.2018.

Research output: Contribution to journalArticle

Quach, Tam T. ; Auvergnon, Nathalie ; Khanna, Rajesh ; Belin, Marie Françoise ; Kolattukudy, Papachan E. ; Honnorat, Jérome ; Duchemin, Anne Marie. / Opposing morphogenetic defects on dendrites and Mossy fibers of dentate granular neurons in CRMP3-deficient mice. In: Brain Sciences. 2018 ; Vol. 8, No. 11.
@article{ac976a37edb54956a8f34d95ab129039,
title = "Opposing morphogenetic defects on dendrites and Mossy fibers of dentate granular neurons in CRMP3-deficient mice",
abstract = "Collapsin response mediator proteins (CRMPs) are highly expressed in the brain during early postnatal development and continue to be present in specific regions into adulthood, especially in areas with extensive neuronal plasticity including the hippocampus. They are found in the axons and dendrites of neurons wherein they contribute to specific signaling mechanisms involved in the regulation of axonal and dendritic development/maintenance. We previously identified CRMP3’s role on the morphology of hippocampal CA1 pyramidal dendrites and hippocampus-dependent functions. Our focus here was to further analyze its role in the dentate gyrus where it is highly expressed during development and in adults. On the basis of our new findings, it appears that CRMP3 has critical roles both in axonal and dendritic morphogenesis of dentate granular neurons. In CRMP3-deficient mice, the dendrites become dystrophic while the infrapyramidal bundle of the mossy fiber shows aberrant extension into the stratum oriens of CA3. This axonal misguided projection of granular neurons suggests that the mossy fiber-CA3 synaptic transmission, important for the evoked propagation of the activity of the hippocampal trisynaptic circuitry, may be altered, whereas the dystrophic dendrites may impair the dynamic interactions with the entorhinal cortex, both expected to affect hippocampal function.",
keywords = "CA3, CRMP3, Dendrite, Dentate granule cells, Dentate gyrus development, Morphogenesis, Mossy fiber",
author = "Quach, {Tam T.} and Nathalie Auvergnon and Rajesh Khanna and Belin, {Marie Fran{\cc}oise} and Kolattukudy, {Papachan E.} and J{\'e}rome Honnorat and Duchemin, {Anne Marie}",
year = "2018",
month = "11",
day = "3",
doi = "10.3390/brainsci8110196",
language = "English (US)",
volume = "8",
journal = "Brain Sciences",
issn = "2076-3425",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "11",

}

TY - JOUR

T1 - Opposing morphogenetic defects on dendrites and Mossy fibers of dentate granular neurons in CRMP3-deficient mice

AU - Quach, Tam T.

AU - Auvergnon, Nathalie

AU - Khanna, Rajesh

AU - Belin, Marie Françoise

AU - Kolattukudy, Papachan E.

AU - Honnorat, Jérome

AU - Duchemin, Anne Marie

PY - 2018/11/3

Y1 - 2018/11/3

N2 - Collapsin response mediator proteins (CRMPs) are highly expressed in the brain during early postnatal development and continue to be present in specific regions into adulthood, especially in areas with extensive neuronal plasticity including the hippocampus. They are found in the axons and dendrites of neurons wherein they contribute to specific signaling mechanisms involved in the regulation of axonal and dendritic development/maintenance. We previously identified CRMP3’s role on the morphology of hippocampal CA1 pyramidal dendrites and hippocampus-dependent functions. Our focus here was to further analyze its role in the dentate gyrus where it is highly expressed during development and in adults. On the basis of our new findings, it appears that CRMP3 has critical roles both in axonal and dendritic morphogenesis of dentate granular neurons. In CRMP3-deficient mice, the dendrites become dystrophic while the infrapyramidal bundle of the mossy fiber shows aberrant extension into the stratum oriens of CA3. This axonal misguided projection of granular neurons suggests that the mossy fiber-CA3 synaptic transmission, important for the evoked propagation of the activity of the hippocampal trisynaptic circuitry, may be altered, whereas the dystrophic dendrites may impair the dynamic interactions with the entorhinal cortex, both expected to affect hippocampal function.

AB - Collapsin response mediator proteins (CRMPs) are highly expressed in the brain during early postnatal development and continue to be present in specific regions into adulthood, especially in areas with extensive neuronal plasticity including the hippocampus. They are found in the axons and dendrites of neurons wherein they contribute to specific signaling mechanisms involved in the regulation of axonal and dendritic development/maintenance. We previously identified CRMP3’s role on the morphology of hippocampal CA1 pyramidal dendrites and hippocampus-dependent functions. Our focus here was to further analyze its role in the dentate gyrus where it is highly expressed during development and in adults. On the basis of our new findings, it appears that CRMP3 has critical roles both in axonal and dendritic morphogenesis of dentate granular neurons. In CRMP3-deficient mice, the dendrites become dystrophic while the infrapyramidal bundle of the mossy fiber shows aberrant extension into the stratum oriens of CA3. This axonal misguided projection of granular neurons suggests that the mossy fiber-CA3 synaptic transmission, important for the evoked propagation of the activity of the hippocampal trisynaptic circuitry, may be altered, whereas the dystrophic dendrites may impair the dynamic interactions with the entorhinal cortex, both expected to affect hippocampal function.

KW - CA3

KW - CRMP3

KW - Dendrite

KW - Dentate granule cells

KW - Dentate gyrus development

KW - Morphogenesis

KW - Mossy fiber

UR - http://www.scopus.com/inward/record.url?scp=85056117323&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85056117323&partnerID=8YFLogxK

U2 - 10.3390/brainsci8110196

DO - 10.3390/brainsci8110196

M3 - Article

AN - SCOPUS:85056117323

VL - 8

JO - Brain Sciences

JF - Brain Sciences

SN - 2076-3425

IS - 11

M1 - 196

ER -