Optical coherence tomography: A novel tool for micron-resolution biomedical diagnostics

Manish D. Kulkarni, Joseph A. Izatt, Kenji Kobayashi, Siavash Yazdanfar, Richard C.K. Wong, Michael V. Sivak, Jennifer K. Barton, Ashley J. Welch

Research output: Contribution to journalConference article

2 Scopus citations

Abstract

Optical coherence tomography (OCT) is a novel method for non-invasive sub-surface imaging of biological tissue micro-structure. OCT is based on low-coherence interferometry. OCT achieves high spatial resolution (approximately 15 μm in three dimensions) and high sensitivity (<-100 dB) in a fiber-optically integrated system which is suitable for application in minimally invasive diagnostics, including endoscopy. We present in vitro cross-sectional OCT images obtained non-invasively in gastrointestinal (GI) tissues to illustrate contrast between histological layers of the GI mucosa and differentiation of the mucosa from submucosa. We also present a novel technique, termed color Doppler OCT (CDOCT) which is an extension of OCT for performing spatially localized optical Doppler velocimetry. We demonstrate micron-scale resolution tomographic imaging of bi-directional blood flow in sub-surface vessels in living tissue using CDOCT. Both OCT and CDOCT have several potential medical applications.

Original languageEnglish (US)
Pages (from-to)883-886
Number of pages4
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
StatePublished - Dec 1 1997
Externally publishedYes
EventProceedings of the 1997 19th Annual International Conference of the IEEE Engineering in Medicine and Biology Society - Chicago, IL, USA
Duration: Oct 30 1997Nov 2 1997

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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    Kulkarni, M. D., Izatt, J. A., Kobayashi, K., Yazdanfar, S., Wong, R. C. K., Sivak, M. V., Barton, J. K., & Welch, A. J. (1997). Optical coherence tomography: A novel tool for micron-resolution biomedical diagnostics. Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, 2, 883-886.