Optical Coherence Tomography in Cardiac Allograft Vasculopathy: State-of-the-Art Review

Deepak Acharya, Renzo Y. Loyaga-Rendon, Arka Chatterjee, Indranee Rajapreyar, Kwan Lee

Research output: Contribution to journalReview articlepeer-review

Abstract

Cardiac allograft vasculopathy (CAV) is a challenging complication of heart transplantation. CAV pathophysiology is incompletely understood, standard screening modalities such as angiography have significant limitations, and currently available therapies have only modest efficacy in preventing progression. Optical coherence tomography is a light-based technique that provides microscopic level catheter-based intravascular imaging and has dramatically expanded our understanding of CAV, demonstrating it to be a complex, heterogeneous, and dynamic process. This review covers characteristics and uses of optical coherence tomography, including vessel characterization, serial use to assess progression of disease, guiding percutaneous intervention, and monitoring response to CAV therapies. We also discuss the potential of optical coherence tomography in providing individualized assessment and enable customized CAV therapies, which may lead to improvements in long-term transplant outcomes.

Original languageEnglish (US)
Pages (from-to)1021-1031
Number of pages11
JournalCirculation: Heart Failure
DOIs
StateAccepted/In press - 2021

Keywords

  • catheter
  • coronary angiography
  • heart transplantation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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