Optical coherence tomography with plasmon resonant nanorods of gold

Timothy S. Troutman, Jennifer K Barton, Marek Romanowski

Research output: Contribution to journalArticle

110 Citations (Scopus)

Abstract

We explored plasmon resonant nanorods of gold as a contrast agent for optical coherence tomography (OCT). Nanorod suspensions were generated through wet chemical synthesis and characterized with spectrophotometry, transmission electron microscopy, and OCT. Polyacrylamide-based phantoms were generated with appropriate scattering and anisotropy coefficients (30 cm-1 and 0.89, respectively) to image distribution of the contrast agent in an environment similar to that of tissue. The observed signal was dependent on whether the plasmon resonance peak overlapped the source bandwidth of the OCT, confirming the resonant character of enhancement. Gold nanorods with plasmon resonance wavelengths overlapping the OCT source yielded a signal-to-background ratio of 4.5 dB, relative to the tissue phantom. Strategies for OCT imaging with nanorods are discussed.

Original languageEnglish (US)
Pages (from-to)1438-1440
Number of pages3
JournalOptics Letters
Volume32
Issue number11
DOIs
StatePublished - Jun 1 2007

Fingerprint

nanorods
tomography
gold
scattering coefficients
spectrophotometry
bandwidth
transmission electron microscopy
anisotropy
augmentation
coefficients
synthesis
wavelengths

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

Cite this

Optical coherence tomography with plasmon resonant nanorods of gold. / Troutman, Timothy S.; Barton, Jennifer K; Romanowski, Marek.

In: Optics Letters, Vol. 32, No. 11, 01.06.2007, p. 1438-1440.

Research output: Contribution to journalArticle

@article{dd86761facc9453a9cd37de8afb38e4e,
title = "Optical coherence tomography with plasmon resonant nanorods of gold",
abstract = "We explored plasmon resonant nanorods of gold as a contrast agent for optical coherence tomography (OCT). Nanorod suspensions were generated through wet chemical synthesis and characterized with spectrophotometry, transmission electron microscopy, and OCT. Polyacrylamide-based phantoms were generated with appropriate scattering and anisotropy coefficients (30 cm-1 and 0.89, respectively) to image distribution of the contrast agent in an environment similar to that of tissue. The observed signal was dependent on whether the plasmon resonance peak overlapped the source bandwidth of the OCT, confirming the resonant character of enhancement. Gold nanorods with plasmon resonance wavelengths overlapping the OCT source yielded a signal-to-background ratio of 4.5 dB, relative to the tissue phantom. Strategies for OCT imaging with nanorods are discussed.",
author = "Troutman, {Timothy S.} and Barton, {Jennifer K} and Marek Romanowski",
year = "2007",
month = "6",
day = "1",
doi = "10.1364/OL.32.001438",
language = "English (US)",
volume = "32",
pages = "1438--1440",
journal = "Optics Letters",
issn = "0146-9592",
publisher = "The Optical Society",
number = "11",

}

TY - JOUR

T1 - Optical coherence tomography with plasmon resonant nanorods of gold

AU - Troutman, Timothy S.

AU - Barton, Jennifer K

AU - Romanowski, Marek

PY - 2007/6/1

Y1 - 2007/6/1

N2 - We explored plasmon resonant nanorods of gold as a contrast agent for optical coherence tomography (OCT). Nanorod suspensions were generated through wet chemical synthesis and characterized with spectrophotometry, transmission electron microscopy, and OCT. Polyacrylamide-based phantoms were generated with appropriate scattering and anisotropy coefficients (30 cm-1 and 0.89, respectively) to image distribution of the contrast agent in an environment similar to that of tissue. The observed signal was dependent on whether the plasmon resonance peak overlapped the source bandwidth of the OCT, confirming the resonant character of enhancement. Gold nanorods with plasmon resonance wavelengths overlapping the OCT source yielded a signal-to-background ratio of 4.5 dB, relative to the tissue phantom. Strategies for OCT imaging with nanorods are discussed.

AB - We explored plasmon resonant nanorods of gold as a contrast agent for optical coherence tomography (OCT). Nanorod suspensions were generated through wet chemical synthesis and characterized with spectrophotometry, transmission electron microscopy, and OCT. Polyacrylamide-based phantoms were generated with appropriate scattering and anisotropy coefficients (30 cm-1 and 0.89, respectively) to image distribution of the contrast agent in an environment similar to that of tissue. The observed signal was dependent on whether the plasmon resonance peak overlapped the source bandwidth of the OCT, confirming the resonant character of enhancement. Gold nanorods with plasmon resonance wavelengths overlapping the OCT source yielded a signal-to-background ratio of 4.5 dB, relative to the tissue phantom. Strategies for OCT imaging with nanorods are discussed.

UR - http://www.scopus.com/inward/record.url?scp=34548455054&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34548455054&partnerID=8YFLogxK

U2 - 10.1364/OL.32.001438

DO - 10.1364/OL.32.001438

M3 - Article

C2 - 17546147

AN - SCOPUS:34548455054

VL - 32

SP - 1438

EP - 1440

JO - Optics Letters

JF - Optics Letters

SN - 0146-9592

IS - 11

ER -