Optical design of an Optical Coherence Tomography and Multispectral Fluorescence Imaging endoscope to detect early stage ovarian cancer

Tyler Tate, Molly Keenan, Elizabeth Swan, John Black, Urs Utzinger, Jennifer Barton

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

The five year survival rate for ovarian cancer is over 90% if early detection occurs, yet no effective early screening method exists. We have designed and are constructing a dual modality Optical Coherence Tomography (OCT) and Multispectral Fluorescence Imaging (MFI) endoscope to optically screen the Fallopian tube and ovary for early stage cancer. The endoscope reaches the ovary via the natural pathway of the vagina, cervix, uterus and Fallopian tube. In order to navigate the Fallopian tube the endoscope must have an outer diameter of 600 μm, be highly flexible, steerable, tracking and nonperforating. The imaging systems consists of six optical subsystems, two from OCT and four from MFI. The optical subsystems have independent and interrelated design criteria. The endoscope will be tested on realistic tissue models and ex vivo tissue to prove feasibility of future human trials. Ultimately the project aims to provide women the first effective ovarian cancer screening technique.

Original languageEnglish (US)
Title of host publicationInternational Optical Design Conference 2014
EditorsMariana Figueiro, Julius Muschaweck, Scott Lerner, John Rogers
PublisherSPIE
ISBN (Electronic)9781628413786
DOIs
StatePublished - Jan 1 2014
EventInternational Optical Design Conference 2014, IODC 2014 - Kohala Coast, United States
Duration: Jun 23 2014Jun 26 2014

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume9293
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Other

OtherInternational Optical Design Conference 2014, IODC 2014
CountryUnited States
CityKohala Coast
Period6/23/146/26/14

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Keywords

  • Endoscopy
  • Fallopian tube
  • Falloposcope
  • Multispectral Fluorescence Imaging
  • OCT
  • Optical Coherence Tomography
  • Ovarian cancer
  • Ovary

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Tate, T., Keenan, M., Swan, E., Black, J., Utzinger, U., & Barton, J. (2014). Optical design of an Optical Coherence Tomography and Multispectral Fluorescence Imaging endoscope to detect early stage ovarian cancer. In M. Figueiro, J. Muschaweck, S. Lerner, & J. Rogers (Eds.), International Optical Design Conference 2014 [92931F] (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 9293). SPIE. https://doi.org/10.1117/12.2073824