Optical model of the blood in large retinal vessels

Kurt R Denninghoff, Matthew H. Smith

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Several optical techniques that investigate blood contained within the retinal vessels are available or under development. We present a mechanical model that simulates the optical properties of the eye, the retinal vessels, and the ocular fundus. A micropipette is chosen as the retinal vessel model, and a mechanical housing is constructed to simulate the eyeball. Spectralon is used to simulate the retinal layers. Filling the eye with fluid index matched to the glass pipette eliminates reflection and refraction effects from the pipette. An apparatus is constructed and used to set the oxygen, nitrogen, and carbon dioxide concentrations in whole human blood. These whole blood samples are pumped through the pipette at 34 μL/min. Measurements made in the model eye closely resemble measurements made in the human eye. This apparatus is useful for developing the science and testing the systems that optically investigate blood and blood flow in the large retinal vessels.

Original languageEnglish (US)
Pages (from-to)371-374
Number of pages4
JournalJournal of Biomedical Optics
Volume5
Issue number4
DOIs
StatePublished - Oct 2000
Externally publishedYes

Fingerprint

Retinal Vessels
pipettes
blood
vessels
Blood
carbon dioxide concentration
nitrogen dioxide
blood flow
Nitrogen Dioxide
dioxides
refraction
Refraction
Carbon Dioxide
Glass
Carbon dioxide
optical properties
Optical properties
glass
fluids
Oxygen

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Radiology Nuclear Medicine and imaging
  • Atomic and Molecular Physics, and Optics
  • Radiological and Ultrasound Technology

Cite this

Optical model of the blood in large retinal vessels. / Denninghoff, Kurt R; Smith, Matthew H.

In: Journal of Biomedical Optics, Vol. 5, No. 4, 10.2000, p. 371-374.

Research output: Contribution to journalArticle

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