Optical-thermal model verification by high-speed optical coherence tomography

Jennifer K Barton, A. Rollins, S. Yazdanfar, T. J. Pfefer, V. Westphal, J. A. Izatt

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

Optical-thermal models that can accurately predict temperature rise and damage in blood vessels and surrounding tissue may be used to improve the treatment of vascular disorders. Verification of these models has been hampered by the lack of time- and depth-resolved experimental data. in vitro and in vivo studies were performed to visualize laser irradiation of blood in cuvettes or cutaneous (hamster dorsal skin flap) blood vessels. Two optical coherence tomography systems, one operating at 400 a-scans per second and the other at 4-30 frames per second, were used. For the in vitro study, a frequency doubled Nd:YAG laser was used (532 nm, 10 ms pulse duration, 2 mm spot size, 10 J/cm2 radiant exposure), in vivo, an Argon laser was employed (ali lines, 0.1-2.0 s pulse duration, 0.1-1.0 mm spot size, 100-400 mW power. Video microscopy images were obtained before and after in vivo irradiations. Time-resolved optical coherence tomography and still images were compared to predictions of temperature rise and damage using Monte Cario and finite difference techniques. In general, predicted damage agreed with actual blood, blood vessel, and surrounding tissue coagulation seen in images. However, limitations of current optical-thermal models were identified, such as the inability to model the dynamic changes in blood optical properties and vessel diameters that were seen in the optical coherence tomography images.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsV.V Tuchin, J.A. Izatt, J.G. Fujimoto
Pages174-182
Number of pages9
Volume4251
DOIs
StatePublished - 2001
EventCoherence Domain Optical Methods in Biomedical Science and Clinical Applications V - San Jose, CA, United States
Duration: Jan 23 2001Jan 24 2001

Other

OtherCoherence Domain Optical Methods in Biomedical Science and Clinical Applications V
CountryUnited States
CitySan Jose, CA
Period1/23/011/24/01

Fingerprint

Optical tomography
blood vessels
Blood vessels
tomography
high speed
blood
Blood
damage
pulse duration
Tissue
Argon lasers
argon lasers
irradiation
hamsters
Laser beam effects
coagulation
Coagulation
vessels
YAG lasers
Laser pulses

Keywords

  • Blood
  • Hamster
  • Monte Carlo
  • Port wine stain
  • Skin flap

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Barton, J. K., Rollins, A., Yazdanfar, S., Pfefer, T. J., Westphal, V., & Izatt, J. A. (2001). Optical-thermal model verification by high-speed optical coherence tomography. In V. V. Tuchin, J. A. Izatt, & J. G. Fujimoto (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4251, pp. 174-182) https://doi.org/10.1117/12.427891

Optical-thermal model verification by high-speed optical coherence tomography. / Barton, Jennifer K; Rollins, A.; Yazdanfar, S.; Pfefer, T. J.; Westphal, V.; Izatt, J. A.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / V.V Tuchin; J.A. Izatt; J.G. Fujimoto. Vol. 4251 2001. p. 174-182.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Barton, JK, Rollins, A, Yazdanfar, S, Pfefer, TJ, Westphal, V & Izatt, JA 2001, Optical-thermal model verification by high-speed optical coherence tomography. in VV Tuchin, JA Izatt & JG Fujimoto (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4251, pp. 174-182, Coherence Domain Optical Methods in Biomedical Science and Clinical Applications V, San Jose, CA, United States, 1/23/01. https://doi.org/10.1117/12.427891
Barton JK, Rollins A, Yazdanfar S, Pfefer TJ, Westphal V, Izatt JA. Optical-thermal model verification by high-speed optical coherence tomography. In Tuchin VV, Izatt JA, Fujimoto JG, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4251. 2001. p. 174-182 https://doi.org/10.1117/12.427891
Barton, Jennifer K ; Rollins, A. ; Yazdanfar, S. ; Pfefer, T. J. ; Westphal, V. ; Izatt, J. A. / Optical-thermal model verification by high-speed optical coherence tomography. Proceedings of SPIE - The International Society for Optical Engineering. editor / V.V Tuchin ; J.A. Izatt ; J.G. Fujimoto. Vol. 4251 2001. pp. 174-182
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