Optical trapping of gold-coated liposomes

S. J. Leung, M. Romanowski

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

To address unmet needs in the area of controlled delivery, we introduced a nanocomposite material, plasmon resonant gold-coated liposomes. We previously showed that gold-coated liposomes display plasmon resonance that is tunable in the near-infrared range and are capable of light-induced content release. The plasmon resonant structure facilitates rapid content release when illuminated with laser light at wavelengths that correspond to the spectral position of the resonance band. Here, we demonstrate optical trapping of gold-coated liposomes that allows for controlled movement of these liposomes within a biological sample. Furthermore, we computationally refined this experimental system with the potential for delivery and localized release of an encapsulated agent with high spatial and temporal resolution. Full development of this technology will enable accurate perturbation of cellular functions in response to released compounds, with applications in signaling pathway research and drug discovery.

Original languageEnglish (US)
Title of host publicationTechnical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
Pages648-651
Number of pages4
StatePublished - Aug 20 2012
EventNanotechnology 2012: Advanced Materials, CNTs, Particles, Films and Composites - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012 - Santa Clara, CA, United States
Duration: Jun 18 2012Jun 21 2012

Publication series

NameTechnical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012

Other

OtherNanotechnology 2012: Advanced Materials, CNTs, Particles, Films and Composites - 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012
CountryUnited States
CitySanta Clara, CA
Period6/18/126/21/12

Keywords

  • Controlled release
  • Liposome
  • Nanoparticle
  • Optical trapping
  • Plasmon resonance

ASJC Scopus subject areas

  • Ceramics and Composites
  • Surfaces, Coatings and Films

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  • Cite this

    Leung, S. J., & Romanowski, M. (2012). Optical trapping of gold-coated liposomes. In Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012 (pp. 648-651). (Technical Proceedings of the 2012 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2012).