Optically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imaging

Shengtao Lin, Anant Shah, Javier Hernandez-Gil, Antonio Stanziola, Bethany Harriss, Terry Matsunaga, Nicholas Long, Jeffrey Bamber, Meng Xing Tang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

To explore the extravascular space, sub-micron phase-change droplets show widespread interest in medical imaging and therapy with various modalities, such as ultrasound and photoacoustic. Existing studies (Wilson 2012, Wei 2014) on such dual-modality contrast agents have demonstrated the generation of both optical and ultrasound contrast after optical activation. However these studies did not explore the option of acoustic activation. Furthermore, high boiling point perfluorocarbons were used in these studies. A low boiling point may be preferred, to minimise un-wanted bioeffects, especially when activating in deeper tissues. In this study, we demonstrate a versatile phase-change sub-micron contrast agent that can provide three modes of contrast enhancement: 1) photoacoustic imaging contrast, 2) ultrasound contrast with optical activation, and 3) ultrasound contrast with acoustic activation. This would add versatility of vaporisation triggering, offering new possibilities in dual mode imaging, molecular imaging and drug delivery.

Original languageEnglish (US)
Title of host publication2017 IEEE International Ultrasonics Symposium, IUS 2017
PublisherIEEE Computer Society
ISBN (Electronic)9781538633830
DOIs
StatePublished - Oct 31 2017
Event2017 IEEE International Ultrasonics Symposium, IUS 2017 - Washington, United States
Duration: Sep 6 2017Sep 9 2017

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727

Other

Other2017 IEEE International Ultrasonics Symposium, IUS 2017
CountryUnited States
CityWashington
Period9/6/179/9/17

ASJC Scopus subject areas

  • Acoustics and Ultrasonics

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  • Cite this

    Lin, S., Shah, A., Hernandez-Gil, J., Stanziola, A., Harriss, B., Matsunaga, T., Long, N., Bamber, J., & Tang, M. X. (2017). Optically and acoustically triggerable sub-micron phase-change contrast agents for enhanced photoacoustic and ultrasound imaging. In 2017 IEEE International Ultrasonics Symposium, IUS 2017 [8092672] (IEEE International Ultrasonics Symposium, IUS). IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2017.8092672