Optimal fluorescence imaging of atherosclerotic human tissue

C. M. Connor Davenport, A. L. Alexander, Arthur F Gmitro

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Multispectral imaging was investigated as a technique to exploit the spatial and spectral information available in the diagnosis of atherosclerosis. A diagnostic system is proposed that could provide direct viewing of a standard endoscopic or a total-fluorescence image. In addition, multiple spectral-feature images, each associated with a separate, narrow spectral band, could be obtained and processed to produce an optimized contrast image. In this study, a 'white-light' image and a total-fluorescence image were obtained. In addition, a three-dimensional, multispectral data set was generated, and two methods of utilizing this data were explored: 1) a per-pixel ratio of fluorescence intensities, and 2) an optimized superposition of the spectral-feature images. Fluorescence imaging is found to provide a rich data set possessing great potential for improving the detection and characterization of atheromatous disease.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsGeorge S. Abela, Abraham Katzir
PublisherPubl by Int Soc for Optical Engineering
Pages16-27
Number of pages12
Volume1425
StatePublished - 1991
EventProceedings of Diagnostic and Therapeutic Cardiovascular Interventions - Los Angeles, CA, USA
Duration: Jan 20 1991Jan 22 1991

Other

OtherProceedings of Diagnostic and Therapeutic Cardiovascular Interventions
CityLos Angeles, CA, USA
Period1/20/911/22/91

Fingerprint

Fluorescence
Tissue
Imaging techniques
fluorescence
arteriosclerosis
image contrast
spectral bands
Pixels
pixels

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Connor Davenport, C. M., Alexander, A. L., & Gmitro, A. F. (1991). Optimal fluorescence imaging of atherosclerotic human tissue. In G. S. Abela, & A. Katzir (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 1425, pp. 16-27). Publ by Int Soc for Optical Engineering.

Optimal fluorescence imaging of atherosclerotic human tissue. / Connor Davenport, C. M.; Alexander, A. L.; Gmitro, Arthur F.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / George S. Abela; Abraham Katzir. Vol. 1425 Publ by Int Soc for Optical Engineering, 1991. p. 16-27.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Connor Davenport, CM, Alexander, AL & Gmitro, AF 1991, Optimal fluorescence imaging of atherosclerotic human tissue. in GS Abela & A Katzir (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 1425, Publ by Int Soc for Optical Engineering, pp. 16-27, Proceedings of Diagnostic and Therapeutic Cardiovascular Interventions, Los Angeles, CA, USA, 1/20/91.
Connor Davenport CM, Alexander AL, Gmitro AF. Optimal fluorescence imaging of atherosclerotic human tissue. In Abela GS, Katzir A, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 1425. Publ by Int Soc for Optical Engineering. 1991. p. 16-27
Connor Davenport, C. M. ; Alexander, A. L. ; Gmitro, Arthur F. / Optimal fluorescence imaging of atherosclerotic human tissue. Proceedings of SPIE - The International Society for Optical Engineering. editor / George S. Abela ; Abraham Katzir. Vol. 1425 Publ by Int Soc for Optical Engineering, 1991. pp. 16-27
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