Optimal search-based gene subset selection for gene array cancer classification

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33 Scopus citations

Abstract

High dimensionality has been a major problem for gene array-based cancer classification. It is critical to identify marker genes for cancer diagnoses. We developed a framework of gene selection methods based on previous studies. This paper focuses on optimal search-based subset selection methods because they evaluate the group performance of genes and help to pinpoint global optimal set of marker genes. Notably, this paper is the first to introduce tabu search (TS) to gene selection from high-dimensional gene array data. Our comparative study of gene selection methods demonstrated the effectiveness of optimal search-based gene subset selection to identify cancer marker genes. TS was shown to be a promising tool for gene subset selection.

Original languageEnglish (US)
Pages (from-to)398-405
Number of pages8
JournalIEEE Transactions on Information Technology in Biomedicine
Volume11
Issue number4
DOIs
StatePublished - Jul 1 2007

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Keywords

  • Genetics
  • Medical diagnosis
  • Optimization methods
  • Pattern classification
  • Search methods

ASJC Scopus subject areas

  • Biotechnology
  • Computer Science Applications
  • Electrical and Electronic Engineering

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