Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates

Ilhem Messaoudi, Miranda Fischer, Jessica Warner, Buyng Park, Julie Mattison, Donald K. Ingram, Thomas Totonchy, Motomi Mori, Janko Nikolich-Zugich

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

We have recently shown in non-human primates that caloric restriction (CR) initiated during adulthood can delay T-cell aging and preserve naïve CD8 and CD4 T cells into advanced age. An important question is whether CR can be initiated at any time in life, and whether age at the time of onset would modulate the beneficial effects of CR. In the current study, we evaluated the impact of CR started before puberty or during advanced age on T-cell senescence and compared it to the effects of CR started in early adulthood. Our data demonstrate that the beneficial effects of adult-onset CR on T-cell aging were lost by both early and late CR onset. In fact, some of our results suggest that inappropriate initiation of CR may be harmful to the maintenance of T-cell function. This suggests that there may be an optimal window during adulthood where CR can delay immune senescence and improve correlates of immunity in primates.

Original languageEnglish (US)
Pages (from-to)908-919
Number of pages12
JournalAging Cell
Volume7
Issue number6
DOIs
StatePublished - 2008

Fingerprint

Caloric Restriction
Cell Aging
Primates
T-Lymphocytes
Puberty
Age of Onset
Immunity
Maintenance

Keywords

  • Caloric restriction
  • Immune senescence
  • Monkeys
  • Tcells

ASJC Scopus subject areas

  • Cell Biology
  • Aging

Cite this

Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates. / Messaoudi, Ilhem; Fischer, Miranda; Warner, Jessica; Park, Buyng; Mattison, Julie; Ingram, Donald K.; Totonchy, Thomas; Mori, Motomi; Nikolich-Zugich, Janko.

In: Aging Cell, Vol. 7, No. 6, 2008, p. 908-919.

Research output: Contribution to journalArticle

Messaoudi, I, Fischer, M, Warner, J, Park, B, Mattison, J, Ingram, DK, Totonchy, T, Mori, M & Nikolich-Zugich, J 2008, 'Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates', Aging Cell, vol. 7, no. 6, pp. 908-919. https://doi.org/10.1111/j.1474-9726.2008.00440.x
Messaoudi, Ilhem ; Fischer, Miranda ; Warner, Jessica ; Park, Buyng ; Mattison, Julie ; Ingram, Donald K. ; Totonchy, Thomas ; Mori, Motomi ; Nikolich-Zugich, Janko. / Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates. In: Aging Cell. 2008 ; Vol. 7, No. 6. pp. 908-919.
@article{018092843a15456a9ac1cc2e269d0788,
title = "Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates",
abstract = "We have recently shown in non-human primates that caloric restriction (CR) initiated during adulthood can delay T-cell aging and preserve na{\"i}ve CD8 and CD4 T cells into advanced age. An important question is whether CR can be initiated at any time in life, and whether age at the time of onset would modulate the beneficial effects of CR. In the current study, we evaluated the impact of CR started before puberty or during advanced age on T-cell senescence and compared it to the effects of CR started in early adulthood. Our data demonstrate that the beneficial effects of adult-onset CR on T-cell aging were lost by both early and late CR onset. In fact, some of our results suggest that inappropriate initiation of CR may be harmful to the maintenance of T-cell function. This suggests that there may be an optimal window during adulthood where CR can delay immune senescence and improve correlates of immunity in primates.",
keywords = "Caloric restriction, Immune senescence, Monkeys, Tcells",
author = "Ilhem Messaoudi and Miranda Fischer and Jessica Warner and Buyng Park and Julie Mattison and Ingram, {Donald K.} and Thomas Totonchy and Motomi Mori and Janko Nikolich-Zugich",
year = "2008",
doi = "10.1111/j.1474-9726.2008.00440.x",
language = "English (US)",
volume = "7",
pages = "908--919",
journal = "Aging Cell",
issn = "1474-9718",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Optimal window of caloric restriction onset limits its beneficial impact on T-cell senescence in primates

AU - Messaoudi, Ilhem

AU - Fischer, Miranda

AU - Warner, Jessica

AU - Park, Buyng

AU - Mattison, Julie

AU - Ingram, Donald K.

AU - Totonchy, Thomas

AU - Mori, Motomi

AU - Nikolich-Zugich, Janko

PY - 2008

Y1 - 2008

N2 - We have recently shown in non-human primates that caloric restriction (CR) initiated during adulthood can delay T-cell aging and preserve naïve CD8 and CD4 T cells into advanced age. An important question is whether CR can be initiated at any time in life, and whether age at the time of onset would modulate the beneficial effects of CR. In the current study, we evaluated the impact of CR started before puberty or during advanced age on T-cell senescence and compared it to the effects of CR started in early adulthood. Our data demonstrate that the beneficial effects of adult-onset CR on T-cell aging were lost by both early and late CR onset. In fact, some of our results suggest that inappropriate initiation of CR may be harmful to the maintenance of T-cell function. This suggests that there may be an optimal window during adulthood where CR can delay immune senescence and improve correlates of immunity in primates.

AB - We have recently shown in non-human primates that caloric restriction (CR) initiated during adulthood can delay T-cell aging and preserve naïve CD8 and CD4 T cells into advanced age. An important question is whether CR can be initiated at any time in life, and whether age at the time of onset would modulate the beneficial effects of CR. In the current study, we evaluated the impact of CR started before puberty or during advanced age on T-cell senescence and compared it to the effects of CR started in early adulthood. Our data demonstrate that the beneficial effects of adult-onset CR on T-cell aging were lost by both early and late CR onset. In fact, some of our results suggest that inappropriate initiation of CR may be harmful to the maintenance of T-cell function. This suggests that there may be an optimal window during adulthood where CR can delay immune senescence and improve correlates of immunity in primates.

KW - Caloric restriction

KW - Immune senescence

KW - Monkeys

KW - Tcells

UR - http://www.scopus.com/inward/record.url?scp=56849113103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=56849113103&partnerID=8YFLogxK

U2 - 10.1111/j.1474-9726.2008.00440.x

DO - 10.1111/j.1474-9726.2008.00440.x

M3 - Article

VL - 7

SP - 908

EP - 919

JO - Aging Cell

JF - Aging Cell

SN - 1474-9718

IS - 6

ER -