Optimizing pyramided transgenic Bt crops for sustainable pest management

Research output: Contribution to journalArticle

119 Citations (Scopus)

Abstract

Transgenic crop pyramids producing two or more Bacillus thuringiensis (Bt) toxins that kill the same insect pest have been widely used to delay evolution of pest resistance. To assess the potential of pyramids to achieve this goal, we analyze data from 38 studies that report effects of ten Bt toxins used in transgenic crops against 15 insect pests. We find that compared with optimal low levels of insect survival, survival on currently used pyramids is often higher for both susceptible insects and insects resistant to one of the toxins in the pyramid. Furthermore, we find that cross-resistance and antagonism between toxins used in pyramids are common, and that these problems are associated with the similarity of the amino acid sequences of domains II and III of the toxins, respectively. This analysis should assist in future pyramid design and the development of sustainable resistance management strategies.

Original languageEnglish (US)
Pages (from-to)161-168
Number of pages8
JournalNature Biotechnology
Volume33
Issue number2
DOIs
StatePublished - 2015

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Pest Control
Bacillus thuringiensis
Bacilli
Crops
Insects
Amino acids
Amino Acids
Conservation of Natural Resources
Amino Acid Sequence

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Biotechnology
  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering

Cite this

Optimizing pyramided transgenic Bt crops for sustainable pest management. / Carriere, Yves; Crickmore, Neil; Tabashnik, Bruce E.

In: Nature Biotechnology, Vol. 33, No. 2, 2015, p. 161-168.

Research output: Contribution to journalArticle

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