Oral intake of purple passion fruit peel extract reduces pain and stiffness and improves physical function in adult patients with knee osteoarthritis

Reza Farid, Zahra Rezaieyazdi, Zahra Mirfeizi, Mohamad Reza Hatef, Mahyar Mirheidari, Hassan Mansouri, Habib Esmaelli, Gayle Bentley, Yinrong Lu, Yeap Foo, Ronald Ross Watson

Research output: Contribution to journalArticle

46 Scopus citations

Abstract

Knee osteoarthritis (OA) is a common degenerative joint disorder and a major cause of pain and disability. The hypothesis tested in this study was that the passion fruit peel extract (PFP), a flavonoid-rich dietary supplement, would reduce symptoms due to knee OA. Thirty-three OA patients were enrolled in a randomized, double-blind, placebo-controlled trial with parallel-group design. Patients received either placebo or PFP pills (150 mg, daily) in a double-blinded fashion for 2 months. The OA clinical symptoms were evaluated monthly with Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index. In the PFP group, there was a significant improvement in total WOMAC score and WOMAC subscale score of physical function after 30 days and pain after 60 days. At 60 days, reductions of 18.6%, 18%, 19.6%, and 19.2% in pain, stiffness, physical function, and composite WOMAC score, respectively, were self-reported in the PFP group. Whereas, in the placebo group, the self-reported WOMAC scores increased in every category. The results of this study show that PFP substantially alleviated osteoarthritis symptoms. This beneficial effect of PFP may be due to its antioxidant and antiinflammatory properties.

Original languageEnglish (US)
Pages (from-to)601-606
Number of pages6
JournalNutrition Research
Volume30
Issue number9
DOIs
StatePublished - Sep 1 2010

Keywords

  • Antioxidant
  • Flavonoid
  • Knee
  • Osteoarthritis
  • Pain
  • Passion fruit

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

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    Farid, R., Rezaieyazdi, Z., Mirfeizi, Z., Hatef, M. R., Mirheidari, M., Mansouri, H., Esmaelli, H., Bentley, G., Lu, Y., Foo, Y., & Watson, R. R. (2010). Oral intake of purple passion fruit peel extract reduces pain and stiffness and improves physical function in adult patients with knee osteoarthritis. Nutrition Research, 30(9), 601-606. https://doi.org/10.1016/j.nutres.2010.08.010