Organic-inorganic nanovesicles for doxorubicin storage and release

Siu Ling Leung, Zhengbao Zha, Weibing Teng, Celine Cohn, Zhifei Dai, Xiaoyi Wu

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The potential of organic-inorganic liposomal cerasomes to store and release doxorubicin (DOX) is investigated. Specifically, cerasomes display sustained DOX release in serum-enriched cell culture medium but minimal drug leakage in deionized water. As revealed by a physics-based model, the medium-sensitive DOX release/leakage is attributed to serum-mediated dissociation of DOX molecules. DOX-loaded cerasomes effectively inhibit the proliferation of human prostate cancer DU145 cells. Furthermore, the kinetics of cerasome uptake/internalization and DOX release correlates well with the time scale for DOX-loaded cerasomes to inhibit the proliferation of the DU145 cells.

Original languageEnglish (US)
Pages (from-to)5756-5764
Number of pages9
JournalSoft Matter
Volume8
Issue number21
DOIs
StatePublished - Jun 7 2012

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

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    Leung, S. L., Zha, Z., Teng, W., Cohn, C., Dai, Z., & Wu, X. (2012). Organic-inorganic nanovesicles for doxorubicin storage and release. Soft Matter, 8(21), 5756-5764. https://doi.org/10.1039/c2sm07452d