Organic-inorganic nanovesicles for doxorubicin storage and release

Siu Ling Leung, Zhengbao Zha, Weibing Teng, Celine Cohn, Zhifei Dai, Xiaoyi Wu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The potential of organic-inorganic liposomal cerasomes to store and release doxorubicin (DOX) is investigated. Specifically, cerasomes display sustained DOX release in serum-enriched cell culture medium but minimal drug leakage in deionized water. As revealed by a physics-based model, the medium-sensitive DOX release/leakage is attributed to serum-mediated dissociation of DOX molecules. DOX-loaded cerasomes effectively inhibit the proliferation of human prostate cancer DU145 cells. Furthermore, the kinetics of cerasome uptake/internalization and DOX release correlates well with the time scale for DOX-loaded cerasomes to inhibit the proliferation of the DU145 cells.

Original languageEnglish (US)
Pages (from-to)5756-5764
Number of pages9
JournalSoft Matter
Volume8
Issue number21
DOIs
StatePublished - Jun 7 2012

Fingerprint

serums
Doxorubicin
leakage
culture media
cells
drugs
cancer
dissociation
physics
kinetics
water
molecules
Deionized water
Cell culture
Culture Media
Physics
Display devices
Molecules
Kinetics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Leung, S. L., Zha, Z., Teng, W., Cohn, C., Dai, Z., & Wu, X. (2012). Organic-inorganic nanovesicles for doxorubicin storage and release. Soft Matter, 8(21), 5756-5764. https://doi.org/10.1039/c2sm07452d

Organic-inorganic nanovesicles for doxorubicin storage and release. / Leung, Siu Ling; Zha, Zhengbao; Teng, Weibing; Cohn, Celine; Dai, Zhifei; Wu, Xiaoyi.

In: Soft Matter, Vol. 8, No. 21, 07.06.2012, p. 5756-5764.

Research output: Contribution to journalArticle

Leung, SL, Zha, Z, Teng, W, Cohn, C, Dai, Z & Wu, X 2012, 'Organic-inorganic nanovesicles for doxorubicin storage and release', Soft Matter, vol. 8, no. 21, pp. 5756-5764. https://doi.org/10.1039/c2sm07452d
Leung, Siu Ling ; Zha, Zhengbao ; Teng, Weibing ; Cohn, Celine ; Dai, Zhifei ; Wu, Xiaoyi. / Organic-inorganic nanovesicles for doxorubicin storage and release. In: Soft Matter. 2012 ; Vol. 8, No. 21. pp. 5756-5764.
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