Ornithine decarboxylase activity and polyamine content in adenocarcinomas of human stomach and large intestine

N. K. Berdinskikh, N. A. Ignatenko, S. P. Zaletok, K. P. Ganina, V. A. Chorniy

Research output: Contribution to journalArticle

42 Scopus citations

Abstract

Ornithine decarboxylase (ODC) activity and differential polyamine composition have been studied in macroscopically normal mucosa, adjacent mucosa, and neoplastic tissue of 95 patients with adenocarcinomas of stomach and large intestine. In tumors, we found increased ODC activity and polyamine content as compared with surrounding mucosa. ODC activity in macroscopically normal tissue of patients with tumors of stomach and large intestine increased as the disease progressed. An inverse relationship was observed between ODC activity in adenocarcinomas and differentiation.

Original languageEnglish (US)
Pages (from-to)496-498
Number of pages3
JournalInternational Journal of Cancer
Volume47
Issue number4
DOIs
StatePublished - Feb 20 1991
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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