Aktivnost' ornitindekarboksilazy i soderzhanie poliaminov pri indutsirovannom 1,2-dimetilgidrazinom kantserogeneze kishechnika u krys.

Translated title of the contribution: Ornithine decarboxylase activity and polyamine contents in 1,2-dimethylhydrazine-induced carcinogenesis of the intestines in rats

N. K. Berdinskikh, Natalia Ignatenko, S. P. Zaletok

Research output: Contribution to journalArticle

Abstract

The ornithine decarboxylase (ODC) activity and concentration of polyamines have been studied in small and large intestine during 1,2-dimethylhydrazine-induced carcinogenesis in rats. Changes in the polyamine biosynthesis consisting both in enhanced ODC activity and an increase of the intracellular content of putrescine, spermidine and spermine. Process of the polyamine synthesis activation proceeds in two phases: the most expressed and similar changes in polyamine metabolism factors have been observed at early (the 1st month) and late (the 5th-6th months) stages of carcinogenesis. It is supposed that intensification of the polyamine synthesis is a typical feature of malignization in the gastrointestinal tract.

Original languageUndefined/Unknown
Pages (from-to)34-36
Number of pages3
JournalEksperimentalnaa onkologia
Volume12
Issue number6
StatePublished - 1990
Externally publishedYes

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1,2-Dimethylhydrazine
Ornithine Decarboxylase
Polyamines
Intestines
Carcinogenesis
Putrescine
Spermidine
Spermine
Large Intestine
Small Intestine
Gastrointestinal Tract

ASJC Scopus subject areas

  • Cancer Research

Cite this

Aktivnost' ornitindekarboksilazy i soderzhanie poliaminov pri indutsirovannom 1,2-dimetilgidrazinom kantserogeneze kishechnika u krys. / Berdinskikh, N. K.; Ignatenko, Natalia; Zaletok, S. P.

In: Eksperimentalnaa onkologia, Vol. 12, No. 6, 1990, p. 34-36.

Research output: Contribution to journalArticle

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abstract = "The ornithine decarboxylase (ODC) activity and concentration of polyamines have been studied in small and large intestine during 1,2-dimethylhydrazine-induced carcinogenesis in rats. Changes in the polyamine biosynthesis consisting both in enhanced ODC activity and an increase of the intracellular content of putrescine, spermidine and spermine. Process of the polyamine synthesis activation proceeds in two phases: the most expressed and similar changes in polyamine metabolism factors have been observed at early (the 1st month) and late (the 5th-6th months) stages of carcinogenesis. It is supposed that intensification of the polyamine synthesis is a typical feature of malignization in the gastrointestinal tract.",
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