Abstract
Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barrett's mucosa from 4 patients with dysplasia, the enzyme activity was greater than in 11 patients without dysplasia (1.6 ± 0.35 vs. 0.19 ± 0.08 U/mg protein; p < 0.005). Increased ornithine decarboxylase activity in biopsy specimens of Barrett's mucosa may represent a marker for dysplasia.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 819-821 |
| Number of pages | 3 |
| Journal | Gastroenterology |
| Volume | 94 |
| Issue number | 3 |
| State | Published - 1988 |
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ASJC Scopus subject areas
- Gastroenterology
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Ornithine decarboxylase activity in Barrett's esophagus : A potential marker for dysplasia. / Garewal, Harinder S.; Sampliner, Richard; Gerner, Eugene; Steinbronn, Karen; Alberts, David; Kendall, Dava.
In: Gastroenterology, Vol. 94, No. 3, 1988, p. 819-821.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Ornithine decarboxylase activity in Barrett's esophagus
T2 - A potential marker for dysplasia
AU - Garewal, Harinder S.
AU - Sampliner, Richard
AU - Gerner, Eugene
AU - Steinbronn, Karen
AU - Alberts, David
AU - Kendall, Dava
PY - 1988
Y1 - 1988
N2 - Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barrett's mucosa from 4 patients with dysplasia, the enzyme activity was greater than in 11 patients without dysplasia (1.6 ± 0.35 vs. 0.19 ± 0.08 U/mg protein; p < 0.005). Increased ornithine decarboxylase activity in biopsy specimens of Barrett's mucosa may represent a marker for dysplasia.
AB - Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barrett's mucosa from 4 patients with dysplasia, the enzyme activity was greater than in 11 patients without dysplasia (1.6 ± 0.35 vs. 0.19 ± 0.08 U/mg protein; p < 0.005). Increased ornithine decarboxylase activity in biopsy specimens of Barrett's mucosa may represent a marker for dysplasia.
UR - http://www.scopus.com/inward/record.url?scp=0023833590&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023833590&partnerID=8YFLogxK
M3 - Article
C2 - 3338650
AN - SCOPUS:0023833590
VL - 94
SP - 819
EP - 821
JO - Gastroenterology
JF - Gastroenterology
SN - 0016-5085
IS - 3
ER -