Ornithine decarboxylase activity in Barrett's esophagus: A potential marker for dysplasia

Harinder S. Garewal, Richard Sampliner, Eugene Gerner, Karen Steinbronn, David Alberts, Dava Kendall

Research output: Contribution to journalArticle

52 Scopus citations

Abstract

Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barrett's mucosa from 4 patients with dysplasia, the enzyme activity was greater than in 11 patients without dysplasia (1.6 ± 0.35 vs. 0.19 ± 0.08 U/mg protein; p < 0.005). Increased ornithine decarboxylase activity in biopsy specimens of Barrett's mucosa may represent a marker for dysplasia.

Original languageEnglish (US)
Pages (from-to)819-821
Number of pages3
JournalGastroenterology
Volume94
Issue number3
DOIs
StatePublished - Mar 1988

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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