Ornithine decarboxylase activity in Barrett's esophagus: A potential marker for dysplasia

Harinder S. Garewal; Richard Sampliner; Eugene Gerner; Karen Steinbronn; David Alberts; Dava Kendall

doi:10.1016/0016-5085(88)90259-4

Ornithine decarboxylase activity in Barrett's esophagus: A potential marker for dysplasia

Harinder S. Garewal, Richard Sampliner, Eugene Gerner, Karen Steinbronn, David Alberts, Dava Kendall

Cancer Center

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Abstract

Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barrett's mucosa from 4 patients with dysplasia, the enzyme activity was greater than in 11 patients without dysplasia (1.6 ± 0.35 vs. 0.19 ± 0.08 U/mg protein; p < 0.005). Increased ornithine decarboxylase activity in biopsy specimens of Barrett's mucosa may represent a marker for dysplasia.

Original language	English (US)
Pages (from-to)	819-821
Number of pages	3
Journal	Gastroenterology
Volume	94
Issue number	3
DOIs	https://doi.org/10.1016/0016-5085(88)90259-4
State	Published - Mar 1988

ASJC Scopus subject areas

Hepatology
Gastroenterology

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abstract = "Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barrett's mucosa from 4 patients with dysplasia, the enzyme activity was greater than in 11 patients without dysplasia (1.6 ± 0.35 vs. 0.19 ± 0.08 U/mg protein; p < 0.005). Increased ornithine decarboxylase activity in biopsy specimens of Barrett's mucosa may represent a marker for dysplasia.",

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T1 - Ornithine decarboxylase activity in Barrett's esophagus

T2 - A potential marker for dysplasia

AU - Garewal, Harinder S.

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AU - Gerner, Eugene

AU - Steinbronn, Karen

AU - Alberts, David

AU - Kendall, Dava

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N2 - Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barrett's mucosa from 4 patients with dysplasia, the enzyme activity was greater than in 11 patients without dysplasia (1.6 ± 0.35 vs. 0.19 ± 0.08 U/mg protein; p < 0.005). Increased ornithine decarboxylase activity in biopsy specimens of Barrett's mucosa may represent a marker for dysplasia.

AB - Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barrett's mucosa from 4 patients with dysplasia, the enzyme activity was greater than in 11 patients without dysplasia (1.6 ± 0.35 vs. 0.19 ± 0.08 U/mg protein; p < 0.005). Increased ornithine decarboxylase activity in biopsy specimens of Barrett's mucosa may represent a marker for dysplasia.

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Ornithine decarboxylase activity in Barrett's esophagus: A potential marker for dysplasia

Abstract

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