Ornithine decarboxylase activity in Barrett's esophagus: A potential marker for dysplasia

Harinder S. Garewal; Richard Sampliner; Eugene Gerner; Karen Steinbronn; David Alberts; Dava Kendall

doi:10.1016/0016-5085(88)90259-4

Ornithine decarboxylase activity in Barrett's esophagus: A potential marker for dysplasia

Harinder S. Garewal, Richard Sampliner, Eugene Gerner, Karen Steinbronn, David Alberts, Dava Kendall

Cancer Center

Research output: Contribution to journal › Article › peer-review

52 Scopus citations

Abstract

Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barrett's mucosa from 4 patients with dysplasia, the enzyme activity was greater than in 11 patients without dysplasia (1.6 ± 0.35 vs. 0.19 ± 0.08 U/mg protein; p < 0.005). Increased ornithine decarboxylase activity in biopsy specimens of Barrett's mucosa may represent a marker for dysplasia.

Original language	English (US)
Pages (from-to)	819-821
Number of pages	3
Journal	Gastroenterology
Volume	94
Issue number	3
DOIs	https://doi.org/10.1016/0016-5085(88)90259-4
State	Published - Mar 1988

ASJC Scopus subject areas

Hepatology
Gastroenterology

Access to Document

10.1016/0016-5085(88)90259-4

Fingerprint Dive into the research topics of 'Ornithine decarboxylase activity in Barrett's esophagus: A potential marker for dysplasia'. Together they form a unique fingerprint.

Cite this

@article{edea1c9684604888b4483dc780d34054,

title = "Ornithine decarboxylase activity in Barrett's esophagus: A potential marker for dysplasia",

abstract = "Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barrett's mucosa from 4 patients with dysplasia, the enzyme activity was greater than in 11 patients without dysplasia (1.6 ± 0.35 vs. 0.19 ± 0.08 U/mg protein; p < 0.005). Increased ornithine decarboxylase activity in biopsy specimens of Barrett's mucosa may represent a marker for dysplasia.",

author = "Garewal, {Harinder S.} and Richard Sampliner and Eugene Gerner and Karen Steinbronn and David Alberts and Dava Kendall",

year = "1988",

month = mar,

doi = "10.1016/0016-5085(88)90259-4",

language = "English (US)",

volume = "94",

pages = "819--821",

journal = "Gastroenterology",

issn = "0016-5085",

publisher = "W.B. Saunders Ltd",

number = "3",

}

TY - JOUR

T1 - Ornithine decarboxylase activity in Barrett's esophagus

T2 - A potential marker for dysplasia

AU - Garewal, Harinder S.

AU - Sampliner, Richard

AU - Gerner, Eugene

AU - Steinbronn, Karen

AU - Alberts, David

AU - Kendall, Dava

PY - 1988/3

Y1 - 1988/3

N2 - Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barrett's mucosa from 4 patients with dysplasia, the enzyme activity was greater than in 11 patients without dysplasia (1.6 ± 0.35 vs. 0.19 ± 0.08 U/mg protein; p < 0.005). Increased ornithine decarboxylase activity in biopsy specimens of Barrett's mucosa may represent a marker for dysplasia.

AB - Ornithine decarboxylase activity is known to be increased in certain premalignant conditions. We determined the activity of this enzyme in mucosal biopsy specimens from 15 patients with Barrett's esophagus. Ornithine decarboxylase was greater in Barrett's mucosa than in squamous esophageal or gastric mucosa. In Barrett's mucosa from 4 patients with dysplasia, the enzyme activity was greater than in 11 patients without dysplasia (1.6 ± 0.35 vs. 0.19 ± 0.08 U/mg protein; p < 0.005). Increased ornithine decarboxylase activity in biopsy specimens of Barrett's mucosa may represent a marker for dysplasia.

UR - http://www.scopus.com/inward/record.url?scp=0023833590&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023833590&partnerID=8YFLogxK

U2 - 10.1016/0016-5085(88)90259-4

DO - 10.1016/0016-5085(88)90259-4

M3 - Article

C2 - 3338650

AN - SCOPUS:0023833590

VL - 94

SP - 819

EP - 821

JO - Gastroenterology

JF - Gastroenterology

SN - 0016-5085

IS - 3

ER -