Ornithyl amphotericin methyl ester treatment of experimental candidiasis in rats

J. N. Galgiani, D. B. VanWyck

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

After intravenous Candida albicans infection, rats received ornithyl amphotericin methyl ester, amphotericin B, or diluent intravenously. At doses of 0.1 and 0.5 mg/kg, the drugs were equally effective in preventing deaths. However, at doses of 2.0 mg/kg, mortality after treatment with amphotericin B was greater than that after placebo, whereas ornithyl amphotericin methyl ester was fully protective.

Original languageEnglish (US)
Pages (from-to)108-109
Number of pages2
JournalAntimicrobial Agents and Chemotherapy
Volume26
Issue number1
DOIs
StatePublished - Jan 1 1984

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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