TY - JOUR
T1 - Ornithyl amphotericin methyl ester treatment of experimental candidiasis in rats
AU - Galgiani, J. N.
AU - VanWyck, D. B.
PY - 1984/1/1
Y1 - 1984/1/1
N2 - After intravenous Candida albicans infection, rats received ornithyl amphotericin methyl ester, amphotericin B, or diluent intravenously. At doses of 0.1 and 0.5 mg/kg, the drugs were equally effective in preventing deaths. However, at doses of 2.0 mg/kg, mortality after treatment with amphotericin B was greater than that after placebo, whereas ornithyl amphotericin methyl ester was fully protective.
AB - After intravenous Candida albicans infection, rats received ornithyl amphotericin methyl ester, amphotericin B, or diluent intravenously. At doses of 0.1 and 0.5 mg/kg, the drugs were equally effective in preventing deaths. However, at doses of 2.0 mg/kg, mortality after treatment with amphotericin B was greater than that after placebo, whereas ornithyl amphotericin methyl ester was fully protective.
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U2 - 10.1128/AAC.26.1.108
DO - 10.1128/AAC.26.1.108
M3 - Article
C2 - 6476814
AN - SCOPUS:0021274906
VL - 26
SP - 108
EP - 109
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
SN - 0066-4804
IS - 1
ER -