Orthologous gene-expression profiling in multi-species models: search for candidate genes.

Dmitry N. Grigoryev, Shwu Fan Ma, Rafael A. Irizarry, Shui Qing Ye, John Quackenbush, Joe GN Garcia

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Microarray-driven gene-expression profiles are generally produced and analyzed for a single specific experimental model. We have assessed an analytical approach that simultaneously evaluates multi-species experimental models within a particular biological condition using orthologous genes as linkers for the various Affymetrix microarray platforms on multi-species models of ventilator-associated lung injury. The results suggest that this approach may be a useful tool in the evaluation of biological processes of interest and selection of process-related candidate genes.

Original languageEnglish (US)
JournalGenome Biology
Volume5
Issue number5
StatePublished - 2004
Externally publishedYes

Fingerprint

Gene Expression Profiling
gene expression
Theoretical Models
Biological Phenomena
gene
Lung Injury
Mechanical Ventilators
Transcriptome
Genes
ventilators
genes
biological processes
lungs

ASJC Scopus subject areas

  • Genetics

Cite this

Grigoryev, D. N., Ma, S. F., Irizarry, R. A., Ye, S. Q., Quackenbush, J., & Garcia, J. GN. (2004). Orthologous gene-expression profiling in multi-species models: search for candidate genes. Genome Biology, 5(5).

Orthologous gene-expression profiling in multi-species models : search for candidate genes. / Grigoryev, Dmitry N.; Ma, Shwu Fan; Irizarry, Rafael A.; Ye, Shui Qing; Quackenbush, John; Garcia, Joe GN.

In: Genome Biology, Vol. 5, No. 5, 2004.

Research output: Contribution to journalArticle

Grigoryev, DN, Ma, SF, Irizarry, RA, Ye, SQ, Quackenbush, J & Garcia, JGN 2004, 'Orthologous gene-expression profiling in multi-species models: search for candidate genes.', Genome Biology, vol. 5, no. 5.
Grigoryev, Dmitry N. ; Ma, Shwu Fan ; Irizarry, Rafael A. ; Ye, Shui Qing ; Quackenbush, John ; Garcia, Joe GN. / Orthologous gene-expression profiling in multi-species models : search for candidate genes. In: Genome Biology. 2004 ; Vol. 5, No. 5.
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