Outcome Comparison between Open and Endovascular Management of TASC II D Aortoiliac Occlusive Disease

Jessica Mayor, Bernardino C. Branco, J. Chung, Miguel F. Montero-Baker, Panagiotis Kougias, Joseph L Mills, Ramyar Gilani

Research output: Contribution to journalArticle

Abstract

Background: Endovascular management of complex aortoiliac occlusive disease (AIOD) has been described as a viable alternative to open surgical reconstruction. To date, few studies have directly compared the 2 techniques. We therefore, evaluated short and mid- term outcomes of open and endovascular therapy in TASC II D AIOD patients. Methods: TASC II D patients undergoing treatment between January 2009 and December 2016 were retrospectively reviewed. Patient demographics, clinical data, and outcomes (complications [technical and systemic] and graft patency) were collected. The primary outcome of this study was primary graft patency. Patients were compared according to treatment group (open versus endovascular). Kaplan-Meier curves were used to analyze follow up results. Results: A total of 75 consecutive patients (open: 30; endovascular: 45) were included in this analysis. In the endovascular group, 25 (55.6%) patients were managed using a hybrid approach with 100% technical success. Critical limb ischemia was the indication for intervention in 16.0% of this cohort (open, 13.3% vs. endovascular, 17.8%, P = 0.397). Overall, there were no significant differences in gender (male: open, 50.0% vs. endovascular, 55.6%, P = 0.637) or age (54.5 ± 5.9 years vs. 57.0 ± 8.7 years, P = 0.171). No in hospital deaths occurred in this cohort. The overall complication rate was significantly higher in the open group (43.3% vs. 17.8%, OR 3.5, 95% CI [1.2–10.1], P = 0.016) with peri-operative systemic complications being more likely in the open cohort (40.0% vs. 6.7%, OR 9.3, 95% CI [2.3–37.3], P < 0.001) while technical complications did not differ between the 2 groups (6.7% vs. 11.1%, OR 0.6, 95% CI [0.1–3.1], P = 0.517). Follow up data was available for 68 patients (90.7%), for a mean of 21.3 ± 17.1 months (range: 1–72 months). Re-intervention rates were significantly higher in the endovascular group (3.3% vs. 20.0%, OR 7.2, 95% CI [1.1–14.3], P = 0.038). The overall primary patency at 2 years was significantly higher in the open group (96.7% vs. 80.0%, OR 7.2, 95% CI [1.2–60.5], P = 0.038). Cox regression analysis revealed separation of the primary outcome for open therapy relative to endovascular repair (log rank, P = 0.320). Conclusions: In this comparison of open and endovascular therapy for complex AIOD, endovascular therapy was associated with high initial technical success and fewer in-hospital systemic complications but also high re-intervention rates when compared to open repair. Further prospective studies aimed at reduction of complications, optimization of patency, and patient selection for such procedures is warranted.

Original languageEnglish (US)
JournalAnnals of Vascular Surgery
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Therapeutics
Transplants
Patient Selection
Ischemia
Extremities
Regression Analysis
Demography
Outcome Assessment (Health Care)
Prospective Studies

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine

Cite this

Outcome Comparison between Open and Endovascular Management of TASC II D Aortoiliac Occlusive Disease. / Mayor, Jessica; Branco, Bernardino C.; Chung, J.; Montero-Baker, Miguel F.; Kougias, Panagiotis; Mills, Joseph L; Gilani, Ramyar.

In: Annals of Vascular Surgery, 01.01.2019.

Research output: Contribution to journalArticle

Mayor, Jessica ; Branco, Bernardino C. ; Chung, J. ; Montero-Baker, Miguel F. ; Kougias, Panagiotis ; Mills, Joseph L ; Gilani, Ramyar. / Outcome Comparison between Open and Endovascular Management of TASC II D Aortoiliac Occlusive Disease. In: Annals of Vascular Surgery. 2019.
@article{5aeeaf6049564b46a8ee78cb431df7ec,
title = "Outcome Comparison between Open and Endovascular Management of TASC II D Aortoiliac Occlusive Disease",
abstract = "Background: Endovascular management of complex aortoiliac occlusive disease (AIOD) has been described as a viable alternative to open surgical reconstruction. To date, few studies have directly compared the 2 techniques. We therefore, evaluated short and mid- term outcomes of open and endovascular therapy in TASC II D AIOD patients. Methods: TASC II D patients undergoing treatment between January 2009 and December 2016 were retrospectively reviewed. Patient demographics, clinical data, and outcomes (complications [technical and systemic] and graft patency) were collected. The primary outcome of this study was primary graft patency. Patients were compared according to treatment group (open versus endovascular). Kaplan-Meier curves were used to analyze follow up results. Results: A total of 75 consecutive patients (open: 30; endovascular: 45) were included in this analysis. In the endovascular group, 25 (55.6{\%}) patients were managed using a hybrid approach with 100{\%} technical success. Critical limb ischemia was the indication for intervention in 16.0{\%} of this cohort (open, 13.3{\%} vs. endovascular, 17.8{\%}, P = 0.397). Overall, there were no significant differences in gender (male: open, 50.0{\%} vs. endovascular, 55.6{\%}, P = 0.637) or age (54.5 ± 5.9 years vs. 57.0 ± 8.7 years, P = 0.171). No in hospital deaths occurred in this cohort. The overall complication rate was significantly higher in the open group (43.3{\%} vs. 17.8{\%}, OR 3.5, 95{\%} CI [1.2–10.1], P = 0.016) with peri-operative systemic complications being more likely in the open cohort (40.0{\%} vs. 6.7{\%}, OR 9.3, 95{\%} CI [2.3–37.3], P < 0.001) while technical complications did not differ between the 2 groups (6.7{\%} vs. 11.1{\%}, OR 0.6, 95{\%} CI [0.1–3.1], P = 0.517). Follow up data was available for 68 patients (90.7{\%}), for a mean of 21.3 ± 17.1 months (range: 1–72 months). Re-intervention rates were significantly higher in the endovascular group (3.3{\%} vs. 20.0{\%}, OR 7.2, 95{\%} CI [1.1–14.3], P = 0.038). The overall primary patency at 2 years was significantly higher in the open group (96.7{\%} vs. 80.0{\%}, OR 7.2, 95{\%} CI [1.2–60.5], P = 0.038). Cox regression analysis revealed separation of the primary outcome for open therapy relative to endovascular repair (log rank, P = 0.320). Conclusions: In this comparison of open and endovascular therapy for complex AIOD, endovascular therapy was associated with high initial technical success and fewer in-hospital systemic complications but also high re-intervention rates when compared to open repair. Further prospective studies aimed at reduction of complications, optimization of patency, and patient selection for such procedures is warranted.",
author = "Jessica Mayor and Branco, {Bernardino C.} and J. Chung and Montero-Baker, {Miguel F.} and Panagiotis Kougias and Mills, {Joseph L} and Ramyar Gilani",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.avsg.2019.06.005",
language = "English (US)",
journal = "Annals of Vascular Surgery",
issn = "0890-5096",
publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - Outcome Comparison between Open and Endovascular Management of TASC II D Aortoiliac Occlusive Disease

AU - Mayor, Jessica

AU - Branco, Bernardino C.

AU - Chung, J.

AU - Montero-Baker, Miguel F.

AU - Kougias, Panagiotis

AU - Mills, Joseph L

AU - Gilani, Ramyar

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Endovascular management of complex aortoiliac occlusive disease (AIOD) has been described as a viable alternative to open surgical reconstruction. To date, few studies have directly compared the 2 techniques. We therefore, evaluated short and mid- term outcomes of open and endovascular therapy in TASC II D AIOD patients. Methods: TASC II D patients undergoing treatment between January 2009 and December 2016 were retrospectively reviewed. Patient demographics, clinical data, and outcomes (complications [technical and systemic] and graft patency) were collected. The primary outcome of this study was primary graft patency. Patients were compared according to treatment group (open versus endovascular). Kaplan-Meier curves were used to analyze follow up results. Results: A total of 75 consecutive patients (open: 30; endovascular: 45) were included in this analysis. In the endovascular group, 25 (55.6%) patients were managed using a hybrid approach with 100% technical success. Critical limb ischemia was the indication for intervention in 16.0% of this cohort (open, 13.3% vs. endovascular, 17.8%, P = 0.397). Overall, there were no significant differences in gender (male: open, 50.0% vs. endovascular, 55.6%, P = 0.637) or age (54.5 ± 5.9 years vs. 57.0 ± 8.7 years, P = 0.171). No in hospital deaths occurred in this cohort. The overall complication rate was significantly higher in the open group (43.3% vs. 17.8%, OR 3.5, 95% CI [1.2–10.1], P = 0.016) with peri-operative systemic complications being more likely in the open cohort (40.0% vs. 6.7%, OR 9.3, 95% CI [2.3–37.3], P < 0.001) while technical complications did not differ between the 2 groups (6.7% vs. 11.1%, OR 0.6, 95% CI [0.1–3.1], P = 0.517). Follow up data was available for 68 patients (90.7%), for a mean of 21.3 ± 17.1 months (range: 1–72 months). Re-intervention rates were significantly higher in the endovascular group (3.3% vs. 20.0%, OR 7.2, 95% CI [1.1–14.3], P = 0.038). The overall primary patency at 2 years was significantly higher in the open group (96.7% vs. 80.0%, OR 7.2, 95% CI [1.2–60.5], P = 0.038). Cox regression analysis revealed separation of the primary outcome for open therapy relative to endovascular repair (log rank, P = 0.320). Conclusions: In this comparison of open and endovascular therapy for complex AIOD, endovascular therapy was associated with high initial technical success and fewer in-hospital systemic complications but also high re-intervention rates when compared to open repair. Further prospective studies aimed at reduction of complications, optimization of patency, and patient selection for such procedures is warranted.

AB - Background: Endovascular management of complex aortoiliac occlusive disease (AIOD) has been described as a viable alternative to open surgical reconstruction. To date, few studies have directly compared the 2 techniques. We therefore, evaluated short and mid- term outcomes of open and endovascular therapy in TASC II D AIOD patients. Methods: TASC II D patients undergoing treatment between January 2009 and December 2016 were retrospectively reviewed. Patient demographics, clinical data, and outcomes (complications [technical and systemic] and graft patency) were collected. The primary outcome of this study was primary graft patency. Patients were compared according to treatment group (open versus endovascular). Kaplan-Meier curves were used to analyze follow up results. Results: A total of 75 consecutive patients (open: 30; endovascular: 45) were included in this analysis. In the endovascular group, 25 (55.6%) patients were managed using a hybrid approach with 100% technical success. Critical limb ischemia was the indication for intervention in 16.0% of this cohort (open, 13.3% vs. endovascular, 17.8%, P = 0.397). Overall, there were no significant differences in gender (male: open, 50.0% vs. endovascular, 55.6%, P = 0.637) or age (54.5 ± 5.9 years vs. 57.0 ± 8.7 years, P = 0.171). No in hospital deaths occurred in this cohort. The overall complication rate was significantly higher in the open group (43.3% vs. 17.8%, OR 3.5, 95% CI [1.2–10.1], P = 0.016) with peri-operative systemic complications being more likely in the open cohort (40.0% vs. 6.7%, OR 9.3, 95% CI [2.3–37.3], P < 0.001) while technical complications did not differ between the 2 groups (6.7% vs. 11.1%, OR 0.6, 95% CI [0.1–3.1], P = 0.517). Follow up data was available for 68 patients (90.7%), for a mean of 21.3 ± 17.1 months (range: 1–72 months). Re-intervention rates were significantly higher in the endovascular group (3.3% vs. 20.0%, OR 7.2, 95% CI [1.1–14.3], P = 0.038). The overall primary patency at 2 years was significantly higher in the open group (96.7% vs. 80.0%, OR 7.2, 95% CI [1.2–60.5], P = 0.038). Cox regression analysis revealed separation of the primary outcome for open therapy relative to endovascular repair (log rank, P = 0.320). Conclusions: In this comparison of open and endovascular therapy for complex AIOD, endovascular therapy was associated with high initial technical success and fewer in-hospital systemic complications but also high re-intervention rates when compared to open repair. Further prospective studies aimed at reduction of complications, optimization of patency, and patient selection for such procedures is warranted.

UR - http://www.scopus.com/inward/record.url?scp=85071859351&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85071859351&partnerID=8YFLogxK

U2 - 10.1016/j.avsg.2019.06.005

DO - 10.1016/j.avsg.2019.06.005

M3 - Article

C2 - 31394230

AN - SCOPUS:85071859351

JO - Annals of Vascular Surgery

JF - Annals of Vascular Surgery

SN - 0890-5096

ER -