Outcomes after esophagectomy

A ten-year prospective cohort

Stephen H. Bailey, David A. Bull, David H. Harpole, Jeffrey J. Rentz, Leigh A Neumayer, Theodore N. Pappas, Jennifer Daley, William G. Henderson, Barbara Krasnicka, Shukri F. Khuri, Douglas E. Wood

Research output: Contribution to journalArticle

322 Citations (Scopus)

Abstract

Background. The Department of Veterans Affairs National Surgical Quality Improvement Program is a unique resource to prospectively analyze surgical outcomes from a cross-section of surgical services nationally. We used this database to assess risk factors for morbidity and mortality after esophagectomy in Veterans Affairs Medical Centers from 1991 to 2001. Methods. A total of 1,777 patients underwent an esophagectomy at 109 Veterans Affairs hospitals with complete in-hospital and 30-day outcomes recorded. Bivariate and multivariable analyses were completed. Results. Thirty-day mortality was 9.8% (174/1,777) and the incidence of one or more of 20 predefined complications was 49.5% (880/1,777). The most frequent postoperative complications were pneumonia in 21% (380/1,777), respiratory failure in 16% (288/1,777), and ventilator support more than 48 hours in 22% (387/1,777). Preoperative predictors of mortality based on multivariable analysis included neoadjuvant therapy, blood urea nitrogen level of more than 40 mg/dL, alkaline phosphatase level of more than 125 U/L, diabetes mellitus, alcohol abuse, decreased functional status, ascites, and increasing age. Preoperative factors impacting morbidity were increasing age, dyspnea, diabetes mellitus, chronic obstructive pulmonary disease, alkaline phosphatase level of more than 125 U/L, lower serum albumin concentration, increased complexity score, and decreased functional status. Intraoperative risk factors for mortality included the need for transfusion; intraoperative risk factors for morbidity included the need for transfusion and longer operative time. Conclusions. These data constitute the largest prospective outcomes cohort in the literature and document a near 50% morbidity rate and 10% mortality rate after esophagectomy. Data from this study can be used to better stratify patients before esophagectomy.

Original languageEnglish (US)
Pages (from-to)217-222
Number of pages6
JournalAnnals of Thoracic Surgery
Volume75
Issue number1
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

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Esophagectomy
Mortality
Morbidity
Veterans
Alkaline Phosphatase
Diabetes Mellitus
Veterans Hospitals
Neoadjuvant Therapy
Blood Urea Nitrogen
Mechanical Ventilators
Operative Time
Quality Improvement
Ascites
Serum Albumin
Respiratory Insufficiency
Dyspnea
Chronic Obstructive Pulmonary Disease
Alcoholism
Pneumonia
Databases

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Bailey, S. H., Bull, D. A., Harpole, D. H., Rentz, J. J., Neumayer, L. A., Pappas, T. N., ... Wood, D. E. (2003). Outcomes after esophagectomy: A ten-year prospective cohort. Annals of Thoracic Surgery, 75(1), 217-222. https://doi.org/10.1016/S0003-4975(02)04368-0

Outcomes after esophagectomy : A ten-year prospective cohort. / Bailey, Stephen H.; Bull, David A.; Harpole, David H.; Rentz, Jeffrey J.; Neumayer, Leigh A; Pappas, Theodore N.; Daley, Jennifer; Henderson, William G.; Krasnicka, Barbara; Khuri, Shukri F.; Wood, Douglas E.

In: Annals of Thoracic Surgery, Vol. 75, No. 1, 01.01.2003, p. 217-222.

Research output: Contribution to journalArticle

Bailey, SH, Bull, DA, Harpole, DH, Rentz, JJ, Neumayer, LA, Pappas, TN, Daley, J, Henderson, WG, Krasnicka, B, Khuri, SF & Wood, DE 2003, 'Outcomes after esophagectomy: A ten-year prospective cohort', Annals of Thoracic Surgery, vol. 75, no. 1, pp. 217-222. https://doi.org/10.1016/S0003-4975(02)04368-0
Bailey, Stephen H. ; Bull, David A. ; Harpole, David H. ; Rentz, Jeffrey J. ; Neumayer, Leigh A ; Pappas, Theodore N. ; Daley, Jennifer ; Henderson, William G. ; Krasnicka, Barbara ; Khuri, Shukri F. ; Wood, Douglas E. / Outcomes after esophagectomy : A ten-year prospective cohort. In: Annals of Thoracic Surgery. 2003 ; Vol. 75, No. 1. pp. 217-222.
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T2 - A ten-year prospective cohort

AU - Bailey, Stephen H.

AU - Bull, David A.

AU - Harpole, David H.

AU - Rentz, Jeffrey J.

AU - Neumayer, Leigh A

AU - Pappas, Theodore N.

AU - Daley, Jennifer

AU - Henderson, William G.

AU - Krasnicka, Barbara

AU - Khuri, Shukri F.

AU - Wood, Douglas E.

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N2 - Background. The Department of Veterans Affairs National Surgical Quality Improvement Program is a unique resource to prospectively analyze surgical outcomes from a cross-section of surgical services nationally. We used this database to assess risk factors for morbidity and mortality after esophagectomy in Veterans Affairs Medical Centers from 1991 to 2001. Methods. A total of 1,777 patients underwent an esophagectomy at 109 Veterans Affairs hospitals with complete in-hospital and 30-day outcomes recorded. Bivariate and multivariable analyses were completed. Results. Thirty-day mortality was 9.8% (174/1,777) and the incidence of one or more of 20 predefined complications was 49.5% (880/1,777). The most frequent postoperative complications were pneumonia in 21% (380/1,777), respiratory failure in 16% (288/1,777), and ventilator support more than 48 hours in 22% (387/1,777). Preoperative predictors of mortality based on multivariable analysis included neoadjuvant therapy, blood urea nitrogen level of more than 40 mg/dL, alkaline phosphatase level of more than 125 U/L, diabetes mellitus, alcohol abuse, decreased functional status, ascites, and increasing age. Preoperative factors impacting morbidity were increasing age, dyspnea, diabetes mellitus, chronic obstructive pulmonary disease, alkaline phosphatase level of more than 125 U/L, lower serum albumin concentration, increased complexity score, and decreased functional status. Intraoperative risk factors for mortality included the need for transfusion; intraoperative risk factors for morbidity included the need for transfusion and longer operative time. Conclusions. These data constitute the largest prospective outcomes cohort in the literature and document a near 50% morbidity rate and 10% mortality rate after esophagectomy. Data from this study can be used to better stratify patients before esophagectomy.

AB - Background. The Department of Veterans Affairs National Surgical Quality Improvement Program is a unique resource to prospectively analyze surgical outcomes from a cross-section of surgical services nationally. We used this database to assess risk factors for morbidity and mortality after esophagectomy in Veterans Affairs Medical Centers from 1991 to 2001. Methods. A total of 1,777 patients underwent an esophagectomy at 109 Veterans Affairs hospitals with complete in-hospital and 30-day outcomes recorded. Bivariate and multivariable analyses were completed. Results. Thirty-day mortality was 9.8% (174/1,777) and the incidence of one or more of 20 predefined complications was 49.5% (880/1,777). The most frequent postoperative complications were pneumonia in 21% (380/1,777), respiratory failure in 16% (288/1,777), and ventilator support more than 48 hours in 22% (387/1,777). Preoperative predictors of mortality based on multivariable analysis included neoadjuvant therapy, blood urea nitrogen level of more than 40 mg/dL, alkaline phosphatase level of more than 125 U/L, diabetes mellitus, alcohol abuse, decreased functional status, ascites, and increasing age. Preoperative factors impacting morbidity were increasing age, dyspnea, diabetes mellitus, chronic obstructive pulmonary disease, alkaline phosphatase level of more than 125 U/L, lower serum albumin concentration, increased complexity score, and decreased functional status. Intraoperative risk factors for mortality included the need for transfusion; intraoperative risk factors for morbidity included the need for transfusion and longer operative time. Conclusions. These data constitute the largest prospective outcomes cohort in the literature and document a near 50% morbidity rate and 10% mortality rate after esophagectomy. Data from this study can be used to better stratify patients before esophagectomy.

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