Outcomes of hyaluronan therapy in diabetic foot wounds

J. R. Vazquez, Brian Short, Andrew H. Findlow, Brent P. Nixon, Andrew J.M. Boulton, David G. Armstrong

Research output: Contribution to journalArticle

61 Scopus citations

Abstract

The purpose of this study was to evaluate outcomes of persons with neuropathic diabetic foot wounds treated with a hyaluronan-containing dressing. Data were abstracted for 36 patients with diabetes, 72.2% male, aged 60.0±10.7 years and a mean glycated hemoglobin (HbA1c) of 9.5±2.5% presenting for care at two large, multidisciplinary wound care centers. All patients received surgical debridement for their diabetic foot wounds and were placed on therapy consisting of hyaluronan dressing (Hyalofill®, Convatec, USA) with dressing changes taking place every other day. Outcomes evaluated included time to complete wound closure and proportion of patients achieving wound closure in 20 weeks. Hyalofill® therapy was used until the wound bed achieved 100% granulation tissue. Therapy was then followed by a moisture-retentive dressing until complete epithelialization. In total, 75.0% of wounds measuring a mean 2.2±2.2 cm2 healed in the 20-week evaluation period. Of those that healed in this period, healing took place in a mean 10.0±4.8 weeks. The average duration of Hyalofill® therapy in all patients was 8.6±4.2 weeks. Deeper (UT Grade 2A) wounds were over 15 times less likely to heal than superficial (1A) wounds (94.7 vs. 52.9%, Odds Ratio=15.9, 95% Confidence Interval=1.7-142.8, P=0.006). We conclude that a regimen consisting of moist wound healing using hyaluronan-containing dressings may be a useful adjunct to appropriate diabetic foot ulcer care. We await the completion of a multicenter randomized controlled trial in this area to either support or refute this initial assessment.

Original languageEnglish (US)
Pages (from-to)123-127
Number of pages5
JournalDiabetes Research and Clinical Practice
Volume59
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Amputation
  • Diabetes
  • Foot
  • Ulcer
  • Wound

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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