Ovarian adenocarcinomas express fms-complementary transcripts and fms antigen, often with coexpression of CSF-1

Barry M. Kacinski, Darryl Carter, Khushbakhat Mittal, Lisa D. Yee, Kimberly A. Scata, Lisa Donofrio, Setsuko K Chambers, Kuan I. Wang, Teresa Yang-Feng, L. R. Rohrschneider, Victoria M. Rothwell

Research output: Contribution to journalArticle

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Abstract

In earlier studies of oncogene expression in ovarian and endometrial neoplasms, the authors reported that high tumor levels of fms-complementary transcripts correlate with high histologic grade and advanced clinical stage presentations. In this communication, they pursue these initial clinicopathologic investigations to demonstrate by in situ hybridization and immunohistochemistry that malignant epithelial cells of M of 14 invasive adenocarcinomas of the ovary express fms-complementary transcripts. By Northern blotting and by reverse transcription, followed by polymerase chain reaction amplification, the authors also were able to demonstrate fms transcript expression in several ovarian and endometrial carcinoma-derived cell lines. Because about half (6/14) of the invasive adenocarcinoma specimens were shown to coexpress fms and colony-stimulating factor 1, the authors propose that the expression of this lymphohematopoietic cytokine and its receptor by ovarian adenocarcinomas could contribute to their proliferative and invasive characteristics in vivo.

Original languageEnglish (US)
Pages (from-to)135-147
Number of pages13
JournalAmerican Journal of Pathology
Volume137
Issue number1
StatePublished - 1990
Externally publishedYes

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Macrophage Colony-Stimulating Factor
Adenocarcinoma
Endometrial Neoplasms
Antigens
Cytokine Receptors
Oncogenes
Northern Blotting
Ovarian Neoplasms
Reverse Transcription
In Situ Hybridization
Ovary
Epithelial Cells
Immunohistochemistry
Cell Line
Polymerase Chain Reaction
Neoplasms

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Kacinski, B. M., Carter, D., Mittal, K., Yee, L. D., Scata, K. A., Donofrio, L., ... Rothwell, V. M. (1990). Ovarian adenocarcinomas express fms-complementary transcripts and fms antigen, often with coexpression of CSF-1. American Journal of Pathology, 137(1), 135-147.

Ovarian adenocarcinomas express fms-complementary transcripts and fms antigen, often with coexpression of CSF-1. / Kacinski, Barry M.; Carter, Darryl; Mittal, Khushbakhat; Yee, Lisa D.; Scata, Kimberly A.; Donofrio, Lisa; Chambers, Setsuko K; Wang, Kuan I.; Yang-Feng, Teresa; Rohrschneider, L. R.; Rothwell, Victoria M.

In: American Journal of Pathology, Vol. 137, No. 1, 1990, p. 135-147.

Research output: Contribution to journalArticle

Kacinski, BM, Carter, D, Mittal, K, Yee, LD, Scata, KA, Donofrio, L, Chambers, SK, Wang, KI, Yang-Feng, T, Rohrschneider, LR & Rothwell, VM 1990, 'Ovarian adenocarcinomas express fms-complementary transcripts and fms antigen, often with coexpression of CSF-1', American Journal of Pathology, vol. 137, no. 1, pp. 135-147.
Kacinski, Barry M. ; Carter, Darryl ; Mittal, Khushbakhat ; Yee, Lisa D. ; Scata, Kimberly A. ; Donofrio, Lisa ; Chambers, Setsuko K ; Wang, Kuan I. ; Yang-Feng, Teresa ; Rohrschneider, L. R. ; Rothwell, Victoria M. / Ovarian adenocarcinomas express fms-complementary transcripts and fms antigen, often with coexpression of CSF-1. In: American Journal of Pathology. 1990 ; Vol. 137, No. 1. pp. 135-147.
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AU - Scata, Kimberly A.

AU - Donofrio, Lisa

AU - Chambers, Setsuko K

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