Ovarian cancer metastatic to the breast presenting as inflammatory breast cancer

A case report and literature review

Rebecca L. Klein, Amanda R. Brown, Christian M. Gomez-Castro, Setsuko K Chambers, Janiel M. Cragun, Lauren Grasso-LeBeau, Julie E. Lang

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background: Primary ovarian carcinoma with metastasis to the breast is rare, with only 39 cases reported in the current literature. Ovarian metastasis to the breast presenting as inflammatory breast carcinoma is even more infrequent, with only 6 cases reported. Case: We present a patient who developed metastatic inflammatory cancer of the breast from a stage IIIC papillary serous ovarian adenocarcinoma approximately 1 year after the original diagnosis. Pathologic analysis confirmed the origin of the tumor: a high-grade adenocarcinoma morphologically similar to the previously diagnosed ovarian cancer. In addition, the tumor was strongly positive on immunohistochemistry for CA-125, identical to the ovarian primary. The patient died of diffuse metastasis 5 months after the breast tumor was noted. Conclusion: Although ovarian metastasis to the breast presenting as inflammatory breast cancer is rare, it should be included in the differential diagnosis for any patient with a personal history of ovarian cancer. Accurate differentiation is necessary because treatment differs significantly for patients with ovarian metastasis to the breast, as compared with patients with primary inflammatory breast cancer. Ovarian metastasis to the breast confers a poor prognosis: patient survival ranged from 3 to 18 months, with a median survival of 6 months after the diagnosis of the breast metastasis.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalJournal of Cancer
Volume1
Issue number1
StatePublished - 2010

Fingerprint

Inflammatory Breast Neoplasms
Ovarian Neoplasms
Breast
Neoplasm Metastasis
Adenocarcinoma
Survival
Neoplasms
Differential Diagnosis
Immunohistochemistry
Breast Neoplasms
Carcinoma

Keywords

  • Breast cancer
  • Breast cancer metastasis
  • Inflammatory breast cancer
  • Ovarian cancer
  • Ovarian cancer metastasis

ASJC Scopus subject areas

  • Oncology

Cite this

Klein, R. L., Brown, A. R., Gomez-Castro, C. M., Chambers, S. K., Cragun, J. M., Grasso-LeBeau, L., & Lang, J. E. (2010). Ovarian cancer metastatic to the breast presenting as inflammatory breast cancer: A case report and literature review. Journal of Cancer, 1(1), 27-31.

Ovarian cancer metastatic to the breast presenting as inflammatory breast cancer : A case report and literature review. / Klein, Rebecca L.; Brown, Amanda R.; Gomez-Castro, Christian M.; Chambers, Setsuko K; Cragun, Janiel M.; Grasso-LeBeau, Lauren; Lang, Julie E.

In: Journal of Cancer, Vol. 1, No. 1, 2010, p. 27-31.

Research output: Contribution to journalArticle

Klein, RL, Brown, AR, Gomez-Castro, CM, Chambers, SK, Cragun, JM, Grasso-LeBeau, L & Lang, JE 2010, 'Ovarian cancer metastatic to the breast presenting as inflammatory breast cancer: A case report and literature review', Journal of Cancer, vol. 1, no. 1, pp. 27-31.
Klein, Rebecca L. ; Brown, Amanda R. ; Gomez-Castro, Christian M. ; Chambers, Setsuko K ; Cragun, Janiel M. ; Grasso-LeBeau, Lauren ; Lang, Julie E. / Ovarian cancer metastatic to the breast presenting as inflammatory breast cancer : A case report and literature review. In: Journal of Cancer. 2010 ; Vol. 1, No. 1. pp. 27-31.
@article{82390ffd487d4410ae08993bdd6fa86b,
title = "Ovarian cancer metastatic to the breast presenting as inflammatory breast cancer: A case report and literature review",
abstract = "Background: Primary ovarian carcinoma with metastasis to the breast is rare, with only 39 cases reported in the current literature. Ovarian metastasis to the breast presenting as inflammatory breast carcinoma is even more infrequent, with only 6 cases reported. Case: We present a patient who developed metastatic inflammatory cancer of the breast from a stage IIIC papillary serous ovarian adenocarcinoma approximately 1 year after the original diagnosis. Pathologic analysis confirmed the origin of the tumor: a high-grade adenocarcinoma morphologically similar to the previously diagnosed ovarian cancer. In addition, the tumor was strongly positive on immunohistochemistry for CA-125, identical to the ovarian primary. The patient died of diffuse metastasis 5 months after the breast tumor was noted. Conclusion: Although ovarian metastasis to the breast presenting as inflammatory breast cancer is rare, it should be included in the differential diagnosis for any patient with a personal history of ovarian cancer. Accurate differentiation is necessary because treatment differs significantly for patients with ovarian metastasis to the breast, as compared with patients with primary inflammatory breast cancer. Ovarian metastasis to the breast confers a poor prognosis: patient survival ranged from 3 to 18 months, with a median survival of 6 months after the diagnosis of the breast metastasis.",
keywords = "Breast cancer, Breast cancer metastasis, Inflammatory breast cancer, Ovarian cancer, Ovarian cancer metastasis",
author = "Klein, {Rebecca L.} and Brown, {Amanda R.} and Gomez-Castro, {Christian M.} and Chambers, {Setsuko K} and Cragun, {Janiel M.} and Lauren Grasso-LeBeau and Lang, {Julie E.}",
year = "2010",
language = "English (US)",
volume = "1",
pages = "27--31",
journal = "Journal of Cancer",
issn = "1837-9664",
publisher = "Ivyspring International Publisher",
number = "1",

}

TY - JOUR

T1 - Ovarian cancer metastatic to the breast presenting as inflammatory breast cancer

T2 - A case report and literature review

AU - Klein, Rebecca L.

AU - Brown, Amanda R.

AU - Gomez-Castro, Christian M.

AU - Chambers, Setsuko K

AU - Cragun, Janiel M.

AU - Grasso-LeBeau, Lauren

AU - Lang, Julie E.

PY - 2010

Y1 - 2010

N2 - Background: Primary ovarian carcinoma with metastasis to the breast is rare, with only 39 cases reported in the current literature. Ovarian metastasis to the breast presenting as inflammatory breast carcinoma is even more infrequent, with only 6 cases reported. Case: We present a patient who developed metastatic inflammatory cancer of the breast from a stage IIIC papillary serous ovarian adenocarcinoma approximately 1 year after the original diagnosis. Pathologic analysis confirmed the origin of the tumor: a high-grade adenocarcinoma morphologically similar to the previously diagnosed ovarian cancer. In addition, the tumor was strongly positive on immunohistochemistry for CA-125, identical to the ovarian primary. The patient died of diffuse metastasis 5 months after the breast tumor was noted. Conclusion: Although ovarian metastasis to the breast presenting as inflammatory breast cancer is rare, it should be included in the differential diagnosis for any patient with a personal history of ovarian cancer. Accurate differentiation is necessary because treatment differs significantly for patients with ovarian metastasis to the breast, as compared with patients with primary inflammatory breast cancer. Ovarian metastasis to the breast confers a poor prognosis: patient survival ranged from 3 to 18 months, with a median survival of 6 months after the diagnosis of the breast metastasis.

AB - Background: Primary ovarian carcinoma with metastasis to the breast is rare, with only 39 cases reported in the current literature. Ovarian metastasis to the breast presenting as inflammatory breast carcinoma is even more infrequent, with only 6 cases reported. Case: We present a patient who developed metastatic inflammatory cancer of the breast from a stage IIIC papillary serous ovarian adenocarcinoma approximately 1 year after the original diagnosis. Pathologic analysis confirmed the origin of the tumor: a high-grade adenocarcinoma morphologically similar to the previously diagnosed ovarian cancer. In addition, the tumor was strongly positive on immunohistochemistry for CA-125, identical to the ovarian primary. The patient died of diffuse metastasis 5 months after the breast tumor was noted. Conclusion: Although ovarian metastasis to the breast presenting as inflammatory breast cancer is rare, it should be included in the differential diagnosis for any patient with a personal history of ovarian cancer. Accurate differentiation is necessary because treatment differs significantly for patients with ovarian metastasis to the breast, as compared with patients with primary inflammatory breast cancer. Ovarian metastasis to the breast confers a poor prognosis: patient survival ranged from 3 to 18 months, with a median survival of 6 months after the diagnosis of the breast metastasis.

KW - Breast cancer

KW - Breast cancer metastasis

KW - Inflammatory breast cancer

KW - Ovarian cancer

KW - Ovarian cancer metastasis

UR - http://www.scopus.com/inward/record.url?scp=79951857398&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79951857398&partnerID=8YFLogxK

M3 - Article

VL - 1

SP - 27

EP - 31

JO - Journal of Cancer

JF - Journal of Cancer

SN - 1837-9664

IS - 1

ER -