Ovarian Lipid Metabolism Modulates Circulating Lipids in Premenopausal Women

Jeffrey T. Jensen, Ilana B. Addis, Jon D. Hennebold, Randy Lloyd Bogan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Context: The premenopausal circulating lipid profile may be linked to the hormonal profile and ovarian lipid metabolism.

Objective: Assess how estradiol, progesterone, and ovarian lipid metabolism contributes to the premenopausal lipid profile; and evaluate the acute effects of a common hormonal oral contraceptive (OC) on circulating lipids.

Design: Experimental crossover with repeated measures.

Setting: Academic hospitals.

Patients: Eight healthy, regularly menstruating women.

Interventions: Participants underwent periodic serum sampling during a normal menstrual cycle; a standard 21-day, monophasic combined hormonal OC cycle (30 µg of ethinyl estradiol and 150 µg of levonorgestrel per day); menopause simulated by leuprolide acetate (22.5-mg depot); and an artificial menstrual cycle achieved via transdermal estradiol (50 to 300 µg/d) and vaginal micronized progesterone (100 to 300 mg/d).

Main Outcome Measures: Primary outcomes included evaluation of total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, triglycerides, and the total cholesterol to HDL cholesterol ratio. To estimate the effect of estradiol, progesterone, and ovarian lipid metabolism, all specimens except those from the OC cycle were analyzed. Subgroup analysis was conducted on the follicular and luteal phases. In a separate analysis, the effect of the OC was evaluated relative to the normal menstrual cycle.

Results: Estradiol was significantly associated with increased levels of HDL cholesterol throughout the menstrual cycle and in the follicular phase. Ovarian effects were associated with reduced lipid levels, especially during the luteal phase. The OC was associated with an increased total cholesterol to HDL cholesterol ratio and triglycerides.

Conclusion: Previously unappreciated factors including ovarian lipid metabolism may contribute to the premenopausal lipid profile.

Original languageEnglish (US)
Pages (from-to)3138-3145
Number of pages8
JournalThe Journal of clinical endocrinology and metabolism
Volume102
Issue number9
DOIs
StatePublished - Sep 1 2017

Fingerprint

Lipid Metabolism
HDL Cholesterol
Estradiol
Contraceptives, Oral, Hormonal
Lipids
Menstrual Cycle
Oral Contraceptives
Progesterone
Follicular Phase
Luteal Phase
Cholesterol
Triglycerides
Leuprolide
Contraceptives, Oral, Combined
Levonorgestrel
Ethinyl Estradiol
Menopause
Design of experiments
LDL Cholesterol
Cross-Over Studies

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Ovarian Lipid Metabolism Modulates Circulating Lipids in Premenopausal Women. / Jensen, Jeffrey T.; Addis, Ilana B.; Hennebold, Jon D.; Bogan, Randy Lloyd.

In: The Journal of clinical endocrinology and metabolism, Vol. 102, No. 9, 01.09.2017, p. 3138-3145.

Research output: Contribution to journalArticle

Jensen, Jeffrey T. ; Addis, Ilana B. ; Hennebold, Jon D. ; Bogan, Randy Lloyd. / Ovarian Lipid Metabolism Modulates Circulating Lipids in Premenopausal Women. In: The Journal of clinical endocrinology and metabolism. 2017 ; Vol. 102, No. 9. pp. 3138-3145.
@article{2801f208d25049769d2a56e76c09e2d6,
title = "Ovarian Lipid Metabolism Modulates Circulating Lipids in Premenopausal Women",
abstract = "Context: The premenopausal circulating lipid profile may be linked to the hormonal profile and ovarian lipid metabolism.Objective: Assess how estradiol, progesterone, and ovarian lipid metabolism contributes to the premenopausal lipid profile; and evaluate the acute effects of a common hormonal oral contraceptive (OC) on circulating lipids.Design: Experimental crossover with repeated measures.Setting: Academic hospitals.Patients: Eight healthy, regularly menstruating women.Interventions: Participants underwent periodic serum sampling during a normal menstrual cycle; a standard 21-day, monophasic combined hormonal OC cycle (30 µg of ethinyl estradiol and 150 µg of levonorgestrel per day); menopause simulated by leuprolide acetate (22.5-mg depot); and an artificial menstrual cycle achieved via transdermal estradiol (50 to 300 µg/d) and vaginal micronized progesterone (100 to 300 mg/d).Main Outcome Measures: Primary outcomes included evaluation of total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, triglycerides, and the total cholesterol to HDL cholesterol ratio. To estimate the effect of estradiol, progesterone, and ovarian lipid metabolism, all specimens except those from the OC cycle were analyzed. Subgroup analysis was conducted on the follicular and luteal phases. In a separate analysis, the effect of the OC was evaluated relative to the normal menstrual cycle.Results: Estradiol was significantly associated with increased levels of HDL cholesterol throughout the menstrual cycle and in the follicular phase. Ovarian effects were associated with reduced lipid levels, especially during the luteal phase. The OC was associated with an increased total cholesterol to HDL cholesterol ratio and triglycerides.Conclusion: Previously unappreciated factors including ovarian lipid metabolism may contribute to the premenopausal lipid profile.",
author = "Jensen, {Jeffrey T.} and Addis, {Ilana B.} and Hennebold, {Jon D.} and Bogan, {Randy Lloyd}",
year = "2017",
month = "9",
day = "1",
doi = "10.1210/jc.2016-3456",
language = "English (US)",
volume = "102",
pages = "3138--3145",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "9",

}

TY - JOUR

T1 - Ovarian Lipid Metabolism Modulates Circulating Lipids in Premenopausal Women

AU - Jensen, Jeffrey T.

AU - Addis, Ilana B.

AU - Hennebold, Jon D.

AU - Bogan, Randy Lloyd

PY - 2017/9/1

Y1 - 2017/9/1

N2 - Context: The premenopausal circulating lipid profile may be linked to the hormonal profile and ovarian lipid metabolism.Objective: Assess how estradiol, progesterone, and ovarian lipid metabolism contributes to the premenopausal lipid profile; and evaluate the acute effects of a common hormonal oral contraceptive (OC) on circulating lipids.Design: Experimental crossover with repeated measures.Setting: Academic hospitals.Patients: Eight healthy, regularly menstruating women.Interventions: Participants underwent periodic serum sampling during a normal menstrual cycle; a standard 21-day, monophasic combined hormonal OC cycle (30 µg of ethinyl estradiol and 150 µg of levonorgestrel per day); menopause simulated by leuprolide acetate (22.5-mg depot); and an artificial menstrual cycle achieved via transdermal estradiol (50 to 300 µg/d) and vaginal micronized progesterone (100 to 300 mg/d).Main Outcome Measures: Primary outcomes included evaluation of total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, triglycerides, and the total cholesterol to HDL cholesterol ratio. To estimate the effect of estradiol, progesterone, and ovarian lipid metabolism, all specimens except those from the OC cycle were analyzed. Subgroup analysis was conducted on the follicular and luteal phases. In a separate analysis, the effect of the OC was evaluated relative to the normal menstrual cycle.Results: Estradiol was significantly associated with increased levels of HDL cholesterol throughout the menstrual cycle and in the follicular phase. Ovarian effects were associated with reduced lipid levels, especially during the luteal phase. The OC was associated with an increased total cholesterol to HDL cholesterol ratio and triglycerides.Conclusion: Previously unappreciated factors including ovarian lipid metabolism may contribute to the premenopausal lipid profile.

AB - Context: The premenopausal circulating lipid profile may be linked to the hormonal profile and ovarian lipid metabolism.Objective: Assess how estradiol, progesterone, and ovarian lipid metabolism contributes to the premenopausal lipid profile; and evaluate the acute effects of a common hormonal oral contraceptive (OC) on circulating lipids.Design: Experimental crossover with repeated measures.Setting: Academic hospitals.Patients: Eight healthy, regularly menstruating women.Interventions: Participants underwent periodic serum sampling during a normal menstrual cycle; a standard 21-day, monophasic combined hormonal OC cycle (30 µg of ethinyl estradiol and 150 µg of levonorgestrel per day); menopause simulated by leuprolide acetate (22.5-mg depot); and an artificial menstrual cycle achieved via transdermal estradiol (50 to 300 µg/d) and vaginal micronized progesterone (100 to 300 mg/d).Main Outcome Measures: Primary outcomes included evaluation of total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, triglycerides, and the total cholesterol to HDL cholesterol ratio. To estimate the effect of estradiol, progesterone, and ovarian lipid metabolism, all specimens except those from the OC cycle were analyzed. Subgroup analysis was conducted on the follicular and luteal phases. In a separate analysis, the effect of the OC was evaluated relative to the normal menstrual cycle.Results: Estradiol was significantly associated with increased levels of HDL cholesterol throughout the menstrual cycle and in the follicular phase. Ovarian effects were associated with reduced lipid levels, especially during the luteal phase. The OC was associated with an increased total cholesterol to HDL cholesterol ratio and triglycerides.Conclusion: Previously unappreciated factors including ovarian lipid metabolism may contribute to the premenopausal lipid profile.

UR - http://www.scopus.com/inward/record.url?scp=85030753389&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030753389&partnerID=8YFLogxK

U2 - 10.1210/jc.2016-3456

DO - 10.1210/jc.2016-3456

M3 - Article

C2 - 28323981

AN - SCOPUS:85030753389

VL - 102

SP - 3138

EP - 3145

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 9

ER -