Ovarian serous carcinoma: Recent concepts on its origin and carcinogenesis

Jie Li, Oluwole Fadare, Li Xiang, Beihua Kong, Wenxin Zheng

Research output: Contribution to journalReview articlepeer-review

86 Scopus citations

Abstract

Recent morphologic and molecular genetic studies have led to a paradigm shift in our conceptualization of the carcinogenesis and histogenesis of pelvic (non-uterine) serous carcinomas. It appears that both low-grade and high-grade pelvic serous carcinomas that have traditionally been classified as ovarian in origin, actually originate, at least in a significant subset, from the distal fallopian tube. Clonal expansions of the tubal secretory cell probably give rise to serous carcinomas, and the degree of ciliated conversion is a function of the degree to which the genetic hits deregulate normal differentiation. In this article, the authors review the evidentiary basis for aforementioned paradigm shift, as well as its potential clinical implications.

Original languageEnglish (US)
Article number8
JournalJournal of Hematology and Oncology
Volume5
DOIs
StatePublished - 2012

Keywords

  • Carcinogenesis
  • Fallopian tube
  • Ovarian cancer
  • Serous carcinoma
  • p53 signatures

ASJC Scopus subject areas

  • Molecular Biology
  • Hematology
  • Oncology
  • Cancer Research

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