Overexpression of follicle-stimulating hormone receptor facilitates the development of ovarian epithelial cancer

Zhenbo Zhang, Lin Jia, Youji Feng, Wenxin Zheng

Research output: Contribution to journalArticle

29 Scopus citations

Abstract

We previously showed that the expressing level of FSH receptor (FSHR) increased from ovarian epithelial inclusions (OEIs) to benign ovarian epithelial tumors (OETs) and to borderline OETs, whereas FSHR levels decreased with an increase in carcinoma grade. The aim of this study was to investigate the role of FSHR in OET development. MCV152 cells with FSHR overexpression showed an increased cellular proliferation and invasive capacity, which was associated with reduced levels of prohibitin and RII-β expression and increased levels of HER-2/neu, c-Myc, and EGFR expression. Overexpression of FSHR may be associated with an elevated level of OET cell proliferation via an enhanced activity of potential oncogenic pathways. Therefore, the findings in this study suggest that overexpression of FSHR may play a role in OET development.

Original languageEnglish (US)
Pages (from-to)56-64
Number of pages9
JournalCancer Letters
Volume278
Issue number1
DOIs
StatePublished - Jun 8 2009

Keywords

  • FSHR
  • Gonadotropin
  • Ovarian cancer

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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