Abstract
Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8079-8084 |
| Number of pages | 6 |
| Journal | Cancer Research |
| Volume | 63 |
| Issue number | 23 |
| State | Published - Dec 1 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability. / Roh, Meejeon; Gary, Bernard; Song, Chisu; Said-Al-Naief, Nasser; Tousson, Albert; Kraft, Andrew; Eltoum, Isam Eldin; Abdulkadir, Sarki A.
In: Cancer Research, Vol. 63, No. 23, 01.12.2003, p. 8079-8084.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability
AU - Roh, Meejeon
AU - Gary, Bernard
AU - Song, Chisu
AU - Said-Al-Naief, Nasser
AU - Tousson, Albert
AU - Kraft, Andrew
AU - Eltoum, Isam Eldin
AU - Abdulkadir, Sarki A.
PY - 2003/12/1
Y1 - 2003/12/1
N2 - Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.
AB - Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.
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UR - http://www.scopus.com/inward/citedby.url?scp=0346995292&partnerID=8YFLogxK
M3 - Article
C2 - 14678956
AN - SCOPUS:0346995292
VL - 63
SP - 8079
EP - 8084
JO - Journal of Cancer Research
JF - Journal of Cancer Research
SN - 0099-7013
IS - 23
ER -