Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability

Meejeon Roh; Bernard Gary; Chisu Song; Nasser Said-Al-Naief; Albert Tousson; Andrew Kraft; Isam Eldin Eltoum; Sarki A. Abdulkadir

Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability

Meejeon Roh, Bernard Gary, Chisu Song, Nasser Said-Al-Naief, Albert Tousson, Andrew Kraft, Isam Eldin Eltoum, Sarki A. Abdulkadir

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.

Original language	English (US)
Pages (from-to)	8079-8084
Number of pages	6
Journal	Cancer Research
Volume	63
Issue number	23
State	Published - Dec 1 2003
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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title = "Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability",

abstract = "Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.",

author = "Meejeon Roh and Bernard Gary and Chisu Song and Nasser Said-Al-Naief and Albert Tousson and Andrew Kraft and Eltoum, {Isam Eldin} and Abdulkadir, {Sarki A.}",

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AU - Roh, Meejeon

AU - Gary, Bernard

AU - Song, Chisu

AU - Said-Al-Naief, Nasser

AU - Tousson, Albert

AU - Kraft, Andrew

AU - Eltoum, Isam Eldin

AU - Abdulkadir, Sarki A.

PY - 2003/12/1

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N2 - Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.

AB - Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.

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