Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability

Meejeon Roh, Bernard Gary, Chisu Song, Nasser Said-Al-Naief, Albert Tousson, Andrew Kraft, Isam Eldin Eltoum, Sarki A. Abdulkadir

Research output: Contribution to journalArticle

72 Scopus citations

Abstract

Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.

Original languageEnglish (US)
Pages (from-to)8079-8084
Number of pages6
JournalCancer Research
Volume63
Issue number23
StatePublished - Dec 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Roh, M., Gary, B., Song, C., Said-Al-Naief, N., Tousson, A., Kraft, A., Eltoum, I. E., & Abdulkadir, S. A. (2003). Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability. Cancer Research, 63(23), 8079-8084.