Abstract
Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 8079-8084 |
| Number of pages | 6 |
| Journal | Cancer Research |
| Volume | 63 |
| Issue number | 23 |
| State | Published - Dec 1 2003 |
| Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research
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Cite this
Roh, M., Gary, B., Song, C., Said-Al-Naief, N., Tousson, A., Kraft, A., Eltoum, I. E., & Abdulkadir, S. A. (2003). Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability. Cancer Research, 63(23), 8079-8084.