TY - JOUR
T1 - Overexpression of the Oncogenic Kinase Pim-1 Leads to Genomic Instability
AU - Roh, Meejeon
AU - Gary, Bernard
AU - Song, Chisu
AU - Said-Al-Naief, Nasser
AU - Tousson, Albert
AU - Kraft, Andrew
AU - Eltoum, Isam Eldin
AU - Abdulkadir, Sarki A.
N1 - Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2003/12/1
Y1 - 2003/12/1
N2 - Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.
AB - Aneuploidy and chromosomal aberrations are hallmarks of most human epithelial malignancies. Here we show that overexpression of the oncogenic kinase Pim-1 in human prostate epithelial cells induces genomic instability by subverting the mitotic spindle checkpoint. Cells overexpressing Pim-1 have a defect in the mitotic spindle checkpoint, abnormal mitotic spindles, centrosome amplification, and chromosome missegregation. Polyploidy and aneuploidy ensue due to a delay in completing cytokinesis. These results define a novel role for elevated Pim-1 expression in promoting genomic instability in human prostate tumors.
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M3 - Article
C2 - 14678956
AN - SCOPUS:0346995292
VL - 63
SP - 8079
EP - 8084
JO - Cancer Research
JF - Cancer Research
SN - 0008-5472
IS - 23
ER -