Oxidosqualene cyclase inhibitors as antimicrobial agents

Jerald C. Hinshaw, Dae Yeon Suh, Philippe Garnier, Frederick S. Buckner, Richard T. Eastman, Seiichi P.T. Matsuda, Bridget M. Joubert, Isabelle Coppens, Keith A. Joiner, Salim Merali, Theodore E. Nash, Glenn D. Prestwich

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Small-molecule oxidosqualene cyclase (OSC) inhibitors were found to be effective in assays against cloned OSC-like enzymes from human pathogens. A combinatorial library was prepared and used to identify lead compounds that inhibit the growth of Trypanosoma cruzi, Leishmania mexicana amazonensis, and Pneumocystis carinii in culture. Selectivity for the microorganisms in preference to mammalian cells was observed.

Original languageEnglish (US)
Pages (from-to)4240-4243
Number of pages4
JournalJournal of Medicinal Chemistry
Volume46
Issue number20
DOIs
StatePublished - Sep 25 2003

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ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

Cite this

Hinshaw, J. C., Suh, D. Y., Garnier, P., Buckner, F. S., Eastman, R. T., Matsuda, S. P. T., Joubert, B. M., Coppens, I., Joiner, K. A., Merali, S., Nash, T. E., & Prestwich, G. D. (2003). Oxidosqualene cyclase inhibitors as antimicrobial agents. Journal of Medicinal Chemistry, 46(20), 4240-4243. https://doi.org/10.1021/jm034126t